{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:52:36Z","timestamp":1776685956225,"version":"3.51.2"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether the presence of brain sparing in fetal growth restricted (FGR) fetuses involves elevation of the cerebral injury biomarker S100B in maternal circulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 63 women with suspected small for gestational age (SGA) fetuses between 24 and 35\u00a0+6\/7\u00a0weeks of gestation. Maternal plasma angiogenic factors measurements and sonographic evaluation were performed at recruitment. Next, we subdivided our SGA cohort into three groups: SGA fetuses, FGR fetuses without brain\u2010sparing, and FGR fetuses with brain\u2010sparing (FGR\u2010BS). Serum S100B concentration was calculated as S100B \u00b5g\/L, S100B MoM, and the ratio S100B\/ estimated fetal weight (EFW). We also report one case of S100B concentration surge in maternal serum following the diagnosis of fetal intraventricular hemorrhage (IVH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The FGR\u2010BS group had higher maternal S100B \u00b5g\/L (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05, respectively), S100B MoM (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, respectively), and S100B\/EFW (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01, respectively), compared to the SGA and FGR groups. In the case report, maternal serum S100B concentrations were 0.0346\u00a0\u00b5g\/L before, and 0.0874\u00a0\u00b5g\/L after IVH occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>S100B concentration in maternal serum increased in pregnancies complicated by FGR and brain sparing. These results may substantiate in\u2010utero cerebral injury and may explain the adverse neurocognitive outcomes reported for this group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6045","type":"journal-article","created":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T22:25:02Z","timestamp":1631831102000},"page":"141-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["S100B in maternal circulation of pregnancies complicated by FGR and brain sparing"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9087-630X","authenticated-orcid":false,"given":"Shani S.","family":"Swissa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center and the Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva 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