{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:12:15Z","timestamp":1775387535894,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T00:00:00Z","timestamp":1635206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the impact of gestational age (GA) at the time of fetal open spinal dysraphism (OSD) repair through a mini\u2010hysterotomy on the ability of children to walk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children who underwent in utero repair of OSD and had formal neurological assessment after 2.5\u00a0years of age were compared regarding their ability to walk in relation to pre\u2010surgical predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010nine children fulfilled the inclusion criteria. Among them, 63.7% (44\/69) were able to walk with or without orthesis. Fetal OSD correction performed earlier in gestation (from 19.7 to 26.9\u00a0weeks) was associated with a higher probability of walking with or without orthesis (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.033). The median GA at delivery was 35.3\u00a0weeks. Multivariate binary logistic regression showed that the upper anatomical level of the OSD (&lt;L4 or &gt; L5) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.004; OR: 10.31 [95% CI: 2.07\u201351.28]) and GA at the time of fetal surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.026; OR\u00a0=\u00a00.68 [95% CI: 0.48\u20130.95]) were independent predictors of the postnatal ability to walk with or without orthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fetuses with OSD who were operated on earlier in pregnancy (range: 19.7\u201326.9\u00a0weeks), were more likely to walk with or without orthesis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6051","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T21:55:00Z","timestamp":1632866100000},"page":"1634-1642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fetal open spinal dysraphism repair through a mini\u2010hysterotomy: Influence of gestational age at surgery on children's ability to walk"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-5311","authenticated-orcid":false,"given":"Cleisson F\u00e1bio Andrioli","family":"Peralta","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine Unit Pro Matre Paulista (Maternity Hospital\u2014Grupo Santa Joana)  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine and Surgery Center (Gestar)  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine Unit CETRUS\u2014S\u00e3o Paulo Ultrasound Training Center  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Davi","family":"Botelho","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit HCor Hospital do Cora\u00e7\u00e3o  S\u00e3o Paulo Brazil"},{"name":"Fetal Medicine Unit Pro Matre Paulista (Maternity 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