{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:54:02Z","timestamp":1786978442497,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize a suggestive prenatal imaging pattern of Aicardi syndrome using ultrasound and MR imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Based on a retrospective international series of Aicardi syndrome cases from tertiary centers encountered over a 20\u2010year period (2000\u20132020), we investigated the frequencies of the imaging features in order to characterize an imaging pattern highly suggestive of the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 20 cases included, arachnoid cysts associated with a distortion of the interhemispheric fissure were constantly encountered associated with complete or partial agenesis of the corpus callosum (19\/20, 95%). This triad in the presence of other CNS disorganization, such as polymicrogyria (16\/17, 94%), heterotopias (15\/17, 88%), ventriculomegaly (14\/20, 70%), cerebral asymmetry [14\/20, 70%]) and less frequently extra\u2010CNS anomaly (ocular anomalies [7\/11, 64%], costal\/vertebral segmentation defect [4\/20, 20%]) represent a highly suggestive pattern of Aicardi syndrome in a female patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite absence of genetic test to confirm prenatal diagnosis of AS, this combination of CNS and extra\u2010CNS fetal findings allows delineation of a characteristic imaging pattern of AS, especially when facing dysgenesis of the corpus callosum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6085","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T22:43:54Z","timestamp":1641336234000},"page":"484-494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prenatal diagnosis of Aicardi syndrome based on a suggestive imaging pattern: A multicenter case\u2010series"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-8129","authenticated-orcid":false,"given":"L\u00e9o","family":"Pomar","sequence":"first","affiliation":[{"name":"Ultrasound and Fetal Medicine, Department Woman\u2010Mother\u2010Child Lausanne University Hospital and Lausanne University  Lausanne Switzerland"},{"name":"School of Health Sciences (HESAV) University of Applied Sciences and Arts Western Switzerland  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Ochoa","sequence":"additional","affiliation":[{"name":"Diagnus SA Prenatal Diagnosis and Fetal Medicine Centre  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-2586","authenticated-orcid":false,"given":"Sara","family":"Cabet","sequence":"additional","affiliation":[{"name":"Pediatric and F\u0153tal Imaging, H\u00f4pital Femme M\u00e8re Enfant Hospices Civils de Lyon Universit\u00e9 Claude Bernard Lyon 1  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry A. G. M.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Edward B. Singleton Department of Radiology Texas Children's Hospital and Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5102-6062","authenticated-orcid":false,"given":"Dario","family":"Paladini","sequence":"additional","affiliation":[{"name":"Fetal Medicine and Surgery Unit Gaslini Children's Hospital  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-4853","authenticated-orcid":false,"given":"Philipp","family":"Klaritsch","sequence":"additional","affiliation":[{"name":"Research Unit for Fetal Medicine Department of Obstetrics and Gynecology Medical University of Graz  Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurore","family":"Galmiche","sequence":"additional","affiliation":[{"name":"Ultrasound and Fetal Medicine Department of Obstetrics Hospital of Niort  Niort 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