{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:47:16Z","timestamp":1780469236157,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T00:00:00Z","timestamp":1642809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Aorto\u2010left ventricular tunnel (ALVT) accounts for &lt;0.1% of congenital heart defects. Evidence on the prognosis from a fetal perspective is limited. With this retrospective international case series, we provide information on the outcome of fetuses with ALVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All members of the Association for European Pediatric and Congenital Cardiology's (AEPC) fetal working group and fetal medicine units worldwide were invited for participation. We observed antenatal parameters, neonatal outcome and postnatal follow\u2010up. Additionally, a systematic search of the literature was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty fetuses with ALVT were identified in 10 participating centers (2001\u20132019). Fetal echocardiographic characteristics of ALVT included an increased cardiac\u2013thorax ratio (95%), left ventricular end\u2010diastolic diameter (90%) and a dysplastic aortic valve (90%). Extracardiac malformations were rare (5%). Eight fetuses died at a median gestational age (GA) of 21\u00a0+\u00a06\u00a0weeks (range, 19\u201324): all showed signs of hydrops prior to 24\u00a0weeks or at autopsy. All others (60%, 12\/2) were live\u2013born (median GA 38\u00a0+\u00a04, range 37\u201340), underwent surgery and were alive at last follow up (median 3.2\u00a0years, range 0.1\u201317). The literature reported 22 ALVT fetuses with similar outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the absence of fetal hydrops, ALVT carries a good prognosis. Fetuses who survive to 24\u00a0weeks without hydrops are likely to have a good outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6090","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T04:35:03Z","timestamp":1641962103000},"page":"267-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The aorto\u2010left ventricular tunnel from a fetal perspective: Original case series and literature review"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1752-5834","authenticated-orcid":false,"given":"Amber E. 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