{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T16:47:55Z","timestamp":1773161275734,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Past studies of fetal tetralogy of fallot (ToF) have reported extra\u2010cardiac anomalies (ECAs) in 17%\u201345%, genetic syndromes in as low as 20% and poor postnatal outcomes. This study sought to examine these factors in a contemporary cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review examining 83 fetuses with ToF diagnosed 2012\u20132019. Referral indication, ToF subtype, additional cardiac, extra\u2010cardiac and genetic diagnoses, pregnancy outcomes and survival were documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean gestational age at diagnosis was 23\u00a0\u00b1\u00a04\u00a0weeks. Of 94% (78\/83) with genetic testing (GT), 30% (23\/78, 95%CI 21%\u201340%) had genetic anomalies (GA), including Trisomy 21 (39%, 9\/23), 22q11 deletion (35%, 8\/23), Trisomy 13 or 18 (17%, 4\/23) and 9% (2\/23) others. A further 4% (3\/78) had VACTERL association. Forty\u2013one percent (34\/83, 95%CI 31%\u201352%) had \u22651 major ECA of whom 41% (14\/34) also had a genetic anomaly. Outcomes: 22% (18\/83) pregnancy termination, 5% (4\/83) intrauterine death and 72% (60\/83) live birth. Of live births, 3% (2\/60) experienced neonatal death, 7% late death (4\/60) and 90% (54\/60) were alive at last follow\u2010up (mean age 3.5\u00a0\u00b1\u00a02.4\u00a0years).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a cohort of fetuses with ToF and high rates of GT, compared to previous reports, GA were more common and there were similar rates of ECAs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6102","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T06:49:36Z","timestamp":1642747776000},"page":"260-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Extra\u2010cardiac diagnoses and postnatal outcomes of fetal tetralogy of fallot"],"prefix":"10.1002","volume":"42","author":[{"given":"Rishav","family":"Sharma","sequence":"first","affiliation":[{"name":"Fetal\u00a0&amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Y.","family":"Niederhoffer","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana","family":"Caluseriu","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy\u2010Lynn","family":"Cooke","sequence":"additional","affiliation":[{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Obstetrics and Gynecology University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-3202","authenticated-orcid":false,"given":"Lisa K.","family":"Hornberger","sequence":"additional","affiliation":[{"name":"Fetal\u00a0&amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"},{"name":"Department of Obstetrics and Gynecology University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"He","sequence":"additional","affiliation":[{"name":"Fetal\u00a0&amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luke","family":"Eckersley","sequence":"additional","affiliation":[{"name":"Fetal\u00a0&amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Lin","sequence":"additional","affiliation":[{"name":"Fetal\u00a0&amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Rushfeldt","sequence":"additional","affiliation":[{"name":"Fetal\u00a0&amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9733-5795","authenticated-orcid":false,"given":"Angela","family":"McBrien","sequence":"additional","affiliation":[{"name":"Fetal\u00a0&amp; Neonatal Cardiology Program Division of Cardiology Department of Pediatrics University of Alberta  Edmonton Alberta Canada"},{"name":"Women's and Children's Health Research Institute University of Alberta  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)01886-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00788220"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12403"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.2009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13274"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017439950142037"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn194"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.82.5.594"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.08040241.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6309"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346564"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000170"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.100"},{"key":"e_1_2_9_15_1","first-page":"e653","article-title":"Genetic basis for congenital heart disease: revisited: a scientific statement from the American heart association","volume":"1382","author":"Pierpont ME","year":"2018","journal-title":"Circulation"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15998"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5979"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-019-0686-8"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.05.007"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00259-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15766"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6102","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.6102","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T03:21:40Z","timestamp":1693106500000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,27]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/pd.6102"],"URL":"https:\/\/doi.org\/10.1002\/pd.6102","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,27]]},"assertion":[{"value":"2021-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}