{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:45:35Z","timestamp":1785581135667,"version":"3.56.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To calculate 3D\u2010segmented total lung volume (TLV) in fetuses with thoracic anomalies using deformable slice\u2010to\u2010volume registration (DSVR) with comparison to 2D\u2010manual segmentation. To establish a normogram of TLV calculated by DSVR in healthy control fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A pilot study at a single regional fetal medicine referral centre included 16 magnetic resonance imaging (MRI) datasets of fetuses (22\u201332\u00a0weeks gestational age). Diagnosis was CDH (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), CPAM (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), and healthy controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a08). Deformable slice\u2010to\u2010volume registration was used for reconstruction of 3D isotropic (0.85\u00a0mm) volumes of the fetal body followed by semi\u2010automated lung segmentation. 3D TLV were compared to traditional 2D\u2010based volumetry. Abnormal cases referenced to a normogram produced from 100 normal fetuses whose TLV was calculated by DSVR only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Deformable slice\u2010to\u2010volume registration\u2010derived TLV values have high correlation with the 2D\u2010based measurements but with a consistently lower volume; bias \u22121.44\u00a0cm<jats:sup>3<\/jats:sup> [95% limits: \u22122.6 to \u22120.3] with improved resolution to exclude hilar structures even in cases of motion corruption or very low lung volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Deformable slice\u2010to\u2010volume registration for fetal lung MRI aids analysis of motion corrupted scans and does not suffer from the interpolation error inherent to 2D\u2010segmentation. It increases information content of acquired data in terms of visualising organs in 3D space and quantification of volumes, which may improve counselling and surgical planning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6129","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T13:43:46Z","timestamp":1646747026000},"page":"628-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Motion corrected fetal body magnetic resonance imaging provides reliable 3D lung volumes in normal and abnormal fetuses"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3303-6320","authenticated-orcid":false,"given":"Joseph","family":"Davidson","sequence":"first","affiliation":[{"name":"Department of Paediatric Surgery Evelina Children's Hospital  London UK"},{"name":"Elizabeth Garrett Anderson Institute of Women's Health University College London  London 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