{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:29:55Z","timestamp":1788218995058,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100014609","name":"Public Health Wales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014609","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the implementation of non\u2010invasive prenatal testing (NIPT) on pregnant women's choices in a national NHS antenatal screening programme for Down's syndrome, Edwards' syndrome and Patau's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>An observational study of all pregnant women with a singleton pregnancy and higher chance (\u22641:150) combined or quadruple screening result from 30 April 2018 to 25 September 2020 in Wales, UK. Pregnant women's journey through the pathway was determined including uptake of NIPT, performance of NIPT in a non\u2010research setting and invasive procedures performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 1273 women with a higher chance initial screening, 1073 (84%) chose NIPT contingent test, 174 (14%) no further testing and 26 (2%) invasive procedure. There were 1001 (93%) low chance NIPT results; 11 (1%) failed results and 61 (6%) high chance results. Average annual incidence of 27 invasive procedures undertaken compared to 229 pre\u2010NIPT implementation, a nearly ninefold reduction. Down's syndrome annual live birth rate remained unchanged across the implementation period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study demonstrates that NIPT contingent screening was highly acceptable to women with a resulting reduction in invasive procedures performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high uptake of NIPT in NHS antenatal screening pathway conditions should inform planning for other national screening programmes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6131","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T16:34:14Z","timestamp":1647102854000},"page":"549-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Implementation of non\u2010invasive prenatal testing within a national UK antenatal screening programme: Impact on women's choices"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1468-3469","authenticated-orcid":false,"given":"Bethan","family":"Bowden","sequence":"first","affiliation":[{"name":"Screening Division Public Health Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sikha","family":"de Souza","sequence":"additional","affiliation":[{"name":"Screening Division Public Health Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Puchades","sequence":"additional","affiliation":[{"name":"Swansea Bay Local Public Health Team Public Health Wales  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kindry","family":"Williams","sequence":"additional","affiliation":[{"name":"Screening Division Public Health Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Morgan","sequence":"additional","affiliation":[{"name":"All Wales Medical Genomics Service University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Anderson","sequence":"additional","affiliation":[{"name":"All Wales Medical Genomics Service University Hospital of Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tucker","sequence":"additional","affiliation":[{"name":"Congenital Anomaly Register\u00a0&amp; Information Service for Wales Singleton Hospital  Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Hillier","sequence":"additional","affiliation":[{"name":"Screening Division Public Health Wales  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Antenatal Screening Wales Policy, Standards and Protocols. Version 2b","author":"Public Health Wales","year":"2019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i3426"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12579"},{"key":"e_1_2_9_5_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Amniocentesis and Chorionic Villus Sampling: Green\u2010top Guideline No. 8; 2021.https:\/\/www.rcog.org.uk\/en\/guidelines\u2010research\u2010services\/guidelines\/gtg8\/"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353523"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2888"},{"key":"e_1_2_9_8_1","unstructured":"UK National Screening Committee. UK NSC non\u2010invasive prenatal testing (NIPT) recommendation. 2016.http:\/\/legacy.screening.nhs.uk\/downs"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102015\u2010010002"},{"key":"e_1_2_9_10_1","volume-title":"Information for Women Offered Further Tests for Suspected Chromosomal Conditions, Version 2","author":"Antenatal Screening Wales","year":"2018"},{"key":"e_1_2_9_11_1","volume-title":"Amniocentesis and Chorionic Villus Sampling: Green\u2010top Guideline No. 8","author":"Royal College of Obstetricians and Gynaecologists","year":"2010"},{"key":"e_1_2_9_12_1","unstructured":"NHS Health Research Authority. HRA Decision Tools: is my study research?http:\/\/www.hra\u2010decisiontools.org.uk\/research\/"},{"key":"e_1_2_9_13_1","unstructured":"Congenital Anomaly Register Service Information.How CARIS works webpage.2020. Accessed January 13 2020.http:\/\/www.caris.wales.nhs.uk\/how\u2010caris\u2010works"},{"key":"e_1_2_9_14_1","volume-title":"Invasive Procedures Review Results 2016","author":"Antenatal Screening Wales","year":"2016"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4125"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.10.005"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14091"},{"key":"e_1_2_9_18_1","unstructured":"Public Health England. NIPT to be evaluated as a new part of NHS screening pathway for Down\u2019s syndrome. Edwards\u2019 syndrome and Patau\u2019s syndrome\u2014PHE Screening;2021. Accessed January 06 2021.blog.gov.uk"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-317031"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897\u2010014\u20109694\u20107"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-016-0012-4"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0000000000000251"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5154"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5182"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6003"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4601"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.6131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T09:21:45Z","timestamp":1692782505000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/pd.6131"],"URL":"https:\/\/doi.org\/10.1002\/pd.6131","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,24]]},"assertion":[{"value":"2021-12-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}