{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:01:28Z","timestamp":1792177288747,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the utility of chromosomal microarray analysis (CMA), for the genetic exploration of isolated and severe intrauterine growth restriction (IUGR) diagnosed before 24\u00a0weeks gestation (WG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included singleton fetuses diagnosed with severe IUGR without structural anomalies before 24 WG referred between 2013 and 2021 who underwent prenatal genetic analysis. IUGR was defined by estimated fetal weight \u22643rd centile for gestational age. Genetic analysis, including QF\u2010PCR and CMA, was systematically offered as part of the etiologic evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 101 referred fetuses, CMA and QF\u2010PCR were performed in 67 fetuses. Among these 67 cases, a total of 10.5% (7\/67) chromosomal abnormalities were detected. CMA detected three pathogenic copy number variants (CNV) (3\/67, 4.5%) and three variants of unknown signification (VUS) (3\/67, 4.5%). Karyotype detected one chromosomal abnormality. All of the QF\u2010PCR were normal. Two fetuses with pathogenic CNV shows Doppler abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study found that in fetuses with severe, isolated, and very early\u2010onset growth restriction, the rate of pathogenic CNV detected by CMA was 4.5%. Although this cohort is too small to draw a definitive conclusion, the presence of Doppler abnormalities couldn't exclude the possibility of genetic abnormalities.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6149","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T07:39:11Z","timestamp":1650008351000},"page":"1281-1287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Utility of chromosomal microarray analysis for the exploration of isolated and severe fetal growth restriction diagnosed before 24\u00a0weeks' gestation"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-1509","authenticated-orcid":false,"given":"Matthieu","family":"Dap","sequence":"first","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit CHRU of Nancy  Nancy France"},{"name":"Department of Fetopathology and Placental Pathology CHRU of Nancy  Nancy France"},{"name":"Universit\u00e9 de Lorraine Inserm IADI  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Gicquel","sequence":"additional","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit CHRU of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics CHRU of Nancy  Nancy France"},{"name":"INSERM UMRS 1256 NGERE, Nutrition, Genetics, and Environmental Risk Exposure Universit\u00e9 de Lorraine  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Perdriolle\u2010Galet","sequence":"additional","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit CHRU of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Bonnet","sequence":"additional","affiliation":[{"name":"INSERM UMRS 1256 NGERE, Nutrition, Genetics, and Environmental Risk Exposure Universit\u00e9 de Lorraine  Nancy France"},{"name":"Genetics Laboratory CHRU of Nancy  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Morel","sequence":"additional","affiliation":[{"name":"Obstetrics and Fetal Medicine Unit CHRU of Nancy  Nancy France"},{"name":"Universit\u00e9 de Lorraine Inserm IADI  Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003070"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgyn.2013.09.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(93)90491-Z"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70388-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970140205"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.1996.tb00990.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.01.003"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001817"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479506"},{"issue":"21","key":"e_1_2_9_11_1","first-page":"00603","article-title":"Should prenatal chromosomal microarray analysis be offered for isolated fetal growth restriction? 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