{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:53:44Z","timestamp":1778810024245,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T00:00:00Z","timestamp":1651881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Key points<\/jats:title><jats:p><jats:bold>What's already known about this topic?<\/jats:bold><\/jats:p><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p>Discordant NIPT results can rarely unravel maternal malignancies, especially when multiple chromosomal imbalances are reported. Both solid and hematological neoplasms have been described.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p><jats:p><jats:bold>What does this study add?<\/jats:bold><\/jats:p><jats:p>\n<jats:list list-type=\"bullet\">\n<jats:list-item>\n<jats:p>This is the first case of a discordant NIPT result due to Chronic Lymphocytic Leukemia associated with trisomy of the chromosome 12. Putative maternal malignancy should be considered and investigated through sensitive techniques even in presence of a single chromosomal anomaly. This must be considered especially when the imbalance is known to recur in hematological neoplasms.<\/jats:p><\/jats:list-item>\n<\/jats:list>\n<\/jats:p>","DOI":"10.1002\/pd.6158","type":"journal-article","created":{"date-parts":[[2022,5,4]],"date-time":"2022-05-04T11:04:35Z","timestamp":1651662275000},"page":"1000-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Discordant cfDNA\u2010NIPT result unraveling a trisomy 12 chronic lymphocytic leukemia in a 37\u00a0years old pregnant woman"],"prefix":"10.1002","volume":"42","author":[{"given":"Niccol\u00f2","family":"Di Giosaffatte","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine Laboratory of Medical Genetics Sapienza University San Camillo\u2010Forlanini Hospital  Rome 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