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A fetal inflammatory response can coexist and is diagnosed on placental histopathology postnatally. Fetal inflammatory response syndrome (FIRS) is associated with poorer fetal and neonatal outcomes. The only antenatal diagnostic test is amniocentesis which carries risks of miscarriage or preterm birth. Imaging of the fetal immune system, in particular the thymus and the spleen, and the placenta may give valuable information antenatally regarding the diagnosis of fetal inflammatory response. While ultrasound is largely limited to structural information, MRI can complement this with functional information that may provide insight into the metabolic activities of the fetal immune system and placenta. This review discusses fetal and placental imaging in pregnancies complicated by chorioamnionitis and their potential future use in achieving non\u2010invasive antenatal diagnosis.<\/jats:p>","DOI":"10.1002\/pd.6188","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T05:28:15Z","timestamp":1654579695000},"page":"1049-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2756-6365","authenticated-orcid":false,"given":"Megan","family":"Hall","sequence":"first","affiliation":[{"name":"Department of Women and Children's Health St Thomas' Hospital King's College  London UK"},{"name":"Centre for the Developing Brain St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Hutter","sequence":"additional","affiliation":[{"name":"Centre for the Developing Brain St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Suff","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Avena Zampieri","sequence":"additional","affiliation":[{"name":"Centre for the Developing Brain St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M.","family":"Tribe","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Shennan","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Centre for the Developing Brain St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Story","sequence":"additional","affiliation":[{"name":"Department of Women and Children's Health St Thomas' Hospital King's College  London UK"},{"name":"Centre for the Developing Brain St Thomas' Hospital King's College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015\u20100225\u2010cc"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101146"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2010.02.003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004471"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2010.96"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.14611"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.03.021"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.07.012"},{"key":"e_1_2_11_10_1","volume-title":"Amnoicentesis and Chorionic Villus Sampling (Green Top Guideline Number 8)","author":"Royal College of Obstetricians and Gynaecologists","year":"2021"},{"key":"e_1_2_11_11_1","unstructured":"Public Health England.UK Standards for Microbiology Investigations: Investigation of Fluids from Normally Sterile Sites."},{"key":"e_1_2_11_12_1","volume-title":"Care of women presenting with suspected preterm prelabour rupture of membranes from 24+0 weeks gestation. 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