{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:26:50Z","timestamp":1777588010683,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Monochorionic twins (MC) are at high risk of adverse outcomes and Doppler investigation of umbilical and cerebral flows is mandatory for their surveillance. The cerebro\u2010placental (CPR) and umbilico\u2010cerebral (UCR) ratios are considered non\u2010invasive measures of fetal adaptation to hypoxemia. We aimed to provide longitudinal references for CPR and UCR from 16 to 37\u00a0weeks of gestation that are specific for MC twins, and compare these with singleton charts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal study of a cohort of consecutive uncomplicated MC twin pregnancies monitored at our unit from 2010 to 2018. The estimated centile curves were obtained estimating the median with fractional polynomials by a multilevel model and the external centiles through the residuals. The comparison with singletons references was made through graphic evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred\u2010fifty\u2010two MC pregnancies were included with a median of 10 longitudinal ultrasounds each. References for CPR and UCR in function of gestational age are presented. Compared to singletons, MC twins showed an earlier and greater circulatory redistribution with lower CPR and higher UCR median values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MC twin\u2010specific references for CPR and UCR suitable for serial monitoring are presented. The comparison with singleton references demonstrates substantial differences in the hemodynamic balance that must be considered when interpreting findings in MC twins.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6210","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T06:54:58Z","timestamp":1657263298000},"page":"1111-1119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebro\u2010placental and umbilico\u2010cerebral ratios in uncomplicated monochorionic twins: Longitudinal references and comparison with singletons"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8856-442X","authenticated-orcid":false,"given":"Daniela","family":"Casati","sequence":"first","affiliation":[{"name":"Department of Woman, Mother and Neonate Buzzi Children's Hospital, ASST Fatebenefratelli Sacco  Milan Italy"},{"name":"Fetal Therapy Unit \u2018Umberto Nicolini\u2019, Department of Woman, Mother and Neonate Buzzi Children's Hospital, ASST Fatebenefratelli Sacco  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Zavatta","sequence":"additional","affiliation":[{"name":"Fetal Therapy Unit \u2018Umberto Nicolini\u2019, Department of Woman, Mother and Neonate Buzzi Children's Hospital, ASST Fatebenefratelli Sacco  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Cortinovis","sequence":"additional","affiliation":[{"name":"Laboratory G.A. 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