{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:42:20Z","timestamp":1787503340977,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are minimal data characterizing the trajectory of left heart growth and hemodynamics following fetal aortic valvuloplasty (FAV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included patients who underwent FAV between 2000 and 2019, with echocardiograms performed pre\u2010FAV, immediately post\u2010FAV, and in late gestation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 118 fetuses undergoing FAV, 106 (90%) underwent technically successful FAV, of which 55 (52%) had biventricular circulation. Technically successful FAV was associated with improved aortic valve growth (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), sustained antegrade aortic arch (AoA) flow (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), improved mitral valve (MV) inflow pattern (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002), and favorable patent foramen ovale (PFO) flow pattern (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004) from pre\u2010FAV to late gestation. Compared to patients with univentricular outcome, patients with biventricular outcome had less decrement in size of the left ventricle (LV) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and aortic valve (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.005), as well as more physiologic PFO flow (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and antegrade AoA flow (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) from pre\u2010FAV to late gestation. In multivariable analysis, echocardiographic predictors of biventricular outcome were less decline in LV end diastolic dimension (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), improved PFO flow (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004), and sustained antegrade AoA flow (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) from pre\u2010FAV to late gestation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Stabilization of left heart growth and improved hemodynamics following successful FAV through late gestation are associated with postnatal biventricular circulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6216","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T03:59:49Z","timestamp":1659585589000},"page":"1312-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hemodynamic and anatomic changes after fetal aortic valvuloplasty are associated with procedural success and postnatal biventricular circulation"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-0035","authenticated-orcid":false,"given":"Victoria R.","family":"Bradford","sequence":"first","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Tworetzky","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Callahan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise E.","family":"Wilkins\u2010Haug","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Obstetrics and Gynecology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol B.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Radiology Brigham and Women's Hospital  Boston Massachusetts 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