{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:16:43Z","timestamp":1775765803778,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T00:00:00Z","timestamp":1661126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate if fetal fraction (FF) reported on cell\u2010free DNA (cfDNA) screening is a marker for adverse obstetric outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed medical records from a cohort of women with singleton pregnancies who had cfDNA screening. We evaluated if reported FF could predict the following pregnancy complications: hypertensive disorders of pregnancy (HDP), fetal growth restriction, preterm delivery, gestational diabetes mellitus, or a composite maternal morbidity, defined as the presence of at least one of these outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Receiver operating curve analysis was performed on FF from 534 women to define the FF that differentiated a low FF group (&lt;10%; <jats:italic>N<\/jats:italic>\u00a0=\u00a0259) and a high FF group (\u226510%; <jats:italic>N<\/jats:italic>\u00a0=\u00a0275). Hypertensive disorders of pregnancy were more common for women in the low FF group (32.0% vs. 11.6% and <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), who had a two\u2010fold odds of developing HDP (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.006). Composite maternal morbidity was also more common for women in the low FF group (51.4% vs. 30.2% and <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), who had a 1.7\u2010fold odds of developing any of the adverse obstetrical outcomes (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We found that low FF on cfDNA screening is associated with an increased risk of HDP. Fetal fraction reported that cfDNA screening reports have potential as a predictive marker for the development of HDP and adverse outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6221","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T17:39:18Z","timestamp":1660066758000},"page":"1253-1261","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lower fetal fraction in clinical cell\u2010free DNA screening results is associated with increased risk of hypertensive disorders of pregnancy"],"prefix":"10.1002","volume":"42","author":[{"given":"Deeksha","family":"Madala","sequence":"first","affiliation":[{"name":"School of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7664-5700","authenticated-orcid":false,"given":"Mohamad 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