{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:31:16Z","timestamp":1779114676368,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61871135"],"award-info":[{"award-number":["61871135"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To establish a classification model for the evaluation of rat fetal lung maturity (FLM) using radiomics technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 430 high\u2010throughput features were extracted per fetal lung image from 134 fetal lung ultrasound images (four\u2010cardiac\u2010chamber views) of 67 Sprague\u2013Dawley (SD) fetal rats with a gestational age of 16\u201321\u00a0days. The detection of fetal lung tissues included histopathological staining and the expression of surface proteins SP\u2010A, SP\u2010B, and SP\u2010C. A machine learning classification model was established using a support vector machine based on histopathological results to analyze the relationship between fetal lung texture characteristics and FLM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rat fetal lungs were divided into two groups: terminal sac period (SD1) and canalicular period (SD2). The mRNA transcription and protein expression level of SP\u2010C protein were significantly higher in the SD1 group than in the SD2 group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The diagnostic performance of the rat FLM classification model was measured as follows: area under the receiver operating characteristic curve (AUC), 0.93 (training set) and 0.89 (validation set); sensitivity, 89.26% (training set) and 87.10% (validation set); specificity, 85.87% (training set) and 79.17% (validation set); and accuracy, 87.79% (training set) and 83.64% (validation set).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ultrasound\u2010based radiomics technology can be used to evaluate the FLM of rats, which lays a foundation for further research on this technology in human fetal lungs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6229","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T09:44:10Z","timestamp":1662198250000},"page":"1429-1437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrasound\u2010based radiomics for the evaluation of fetal rat lung maturity: A noninvasive assessment method (Ultrasound\u2010based radiomics in fetal rat lung)"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9070-0526","authenticated-orcid":false,"given":"Yanran","family":"Du","sequence":"first","affiliation":[{"name":"Department of Ultrasound Ruijin Hospital Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Electronic Engineering Fudan University  Shanghai China"},{"name":"Key Laboratory of Medical Imaging Computing and Computer\u2010Assisted Intervention  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aili","family":"Cao","sequence":"additional","affiliation":[{"name":"Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ji","sequence":"additional","affiliation":[{"name":"Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Li","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenli","family":"Ji","sequence":"additional","affiliation":[{"name":"Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Wu","sequence":"additional","affiliation":[{"name":"Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai 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