{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:54:58Z","timestamp":1775465698286,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to determine foetal losses for DCDA and MCDA twins following transabdominal CVS or amniocentesis performed &lt;22+<jats:sup>0<\/jats:sup>\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study conducted in the UK and Belgium 01\/01\/00\u201301\/06\/20. Cases with unknown chorionicity, monochorionic complications or complex procedures were excluded. Uncomplicated DCDA and MCDA twins without invasive procedures were identified as controls. We reported foetal losses &lt;24+<jats:sup>0<\/jats:sup>\u00a0weeks and losses of genetically and structurally normal foetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Outcomes were compared for DCDA foetuses; 258 after CVS with 3406 controls, 406 after amniocentesis with 3390 controls plus MCDA foetuses, 98 after CVS with 1124 controls, and 160 after amniocentesis with 1122 controls. There were more losses &lt;24+<jats:sup>0<\/jats:sup>\u00a0weeks with both procedures in DCDA (CVS RR 5.54 95% CI 3.38\u20139.08, amniocentesis RR 2.36 95% CI 1.22\u20134.56) and MCDA twins (CVS RR 5.14 95% CI 2.51\u201310.54, amniocentesis RR 7.01 95% CI 3.86\u201312.74). Losses of normal foetuses were comparable to controls (DCDA CVS RR 0.39 95% CI 0.05\u20132.83, DCDA amniocentesis RR 1.16 95% CI 0.42\u20133.22, MCDA CVS RR 2.3 95% CI 0.71\u20137.56, and MCDA amniocentesis RR 1.93 95% CI 0.59\u20136.38).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study indicates increased foetal losses for DCDA and MCDA twins following CVS and amniocentesis with uncertain risk to normal foetuses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6237","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T04:58:37Z","timestamp":1663045117000},"page":"1554-1561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Foetal loss after chorionic villus sampling and amniocentesis in twin pregnancies: A multicentre retrospective cohort study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0888-1650","authenticated-orcid":false,"given":"Kate","family":"Navaratnam","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Liverpool Women\u2019s Hospital  Liverpool UK"},{"name":"Harris\u2010Wellbeing Research Centre University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delima","family":"Khairudin","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Liverpool Women\u2019s Hospital  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn","family":"Chilton","sequence":"additional","affiliation":[{"name":"Harris\u2010Wellbeing Research Centre University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Sharp","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Liverpool Women\u2019s Hospital  Liverpool UK"},{"name":"Harris\u2010Wellbeing Research Centre University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Attilakos","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University College London Hospital NHS Foundation Trust and Institute for Women's Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Stott","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University College London Hospital NHS Foundation Trust and Institute for Women's Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Relph","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit University College London Hospital NHS Foundation Trust and Institute for Women's Health University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Spencer","sequence":"additional","affiliation":[{"name":"University of Leeds and Fetal Medicine Unit Leeds Teaching Hospitals NHS Trust  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique A.","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Carlin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Jani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Kilby","sequence":"additional","affiliation":[{"name":"Institute of Metabolism &amp; 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