{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:38:03Z","timestamp":1788194283628,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate preferences of pregnant women for the characteristics of prenatal testing, and to quantify their willingness\u2010to\u2010pay (WTP) for non\u2010invasive prenatal testing (NIPT) as first\u2010line screening for Down Syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A cross\u2010sectional discrete choice experiment survey including five testing attributes was administered to 192 pregnant women (\u226414\u00a0weeks' gestation) who were aged \u226521\u00a0years in Singapore. We calculated marginal WTP for improvements in testing characteristics and NIPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified two groups of women with distinct preferences for prenatal testing. Women aged \u226535\u00a0years, with at least a university education, and with intention to terminate pregnancy of an affected fetus were more likely to be in the group with higher WTP for improvements in test characteristics. While participants valued increased detection rate and lower screen positive rate associated with NIPT, they also valued no risk of test failure and ability to test for birth defects using standard testing. The participants, on average, were not willing to pay for NIPT over the standard testing as a first\u2010line screening test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As a first\u2010line screening, NIPT was not preferred over standard testing. The prenatal consultations should focus on each testing characteristic equally as our findings show diverse preferences for testing characteristics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6239","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T05:28:42Z","timestamp":1662960522000},"page":"1368-1376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preferences for a non\u2010invasive prenatal test as first\u2010line screening for Down Syndrome: A discrete choice experiment"],"prefix":"10.1002","volume":"42","author":[{"given":"Wen Shan","family":"Sim","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine KK Women's and Children's Hospital  Singapore Singapore"},{"name":"Antenatal Diagnostic Centre KK Women's and Children's Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seow 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