{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:47:01Z","timestamp":1791283621803,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the common and severe maternal morbidities associated with medical termination of pregnancy (MTOP) for fetal anomaly \u226520\u00a0weeks' gestation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 10\u2010year retrospective cohort study (January 2010\u2013December 2019) analyzing 407 consecutive singleton pregnancies MTOP for fetal anomaly \u226520\u00a0weeks' gestation, at a quaternary maternity centre in Australia (Royal Women's Hospital, Melbourne).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort comprised of 191 primiparous and 216 multiparous women, of whom 75 (34.7%) had at least one prior Cesarean; 13 women had a low\u2010lying placenta or placenta praevia. The average gestation was 23\u00a0weeks (interquartile range 22\u201326\u00a0weeks). A spontaneous unassisted vaginal delivery was achieved by the majority (<jats:italic>n<\/jats:italic>\u00a0=\u00a0403, 99.0%). The most common maternal morbidities were transferred to the theater for manual removal of retained placental tissue (<jats:italic>n<\/jats:italic>\u00a0=\u00a065, 16.0%) and postpartum haemorrhage (PPH) (<jats:italic>n<\/jats:italic>\u00a0=\u00a045, 11.1%). Severe maternal morbidity occurred in six cases (1.3%) and included amniotic fluid embolism, cardiac arrest, major obstetric haemorrhage, uterine rupture and intensive care unit admission. There were no maternal deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The most common complications of MTOP for fetal anomaly \u226520\u00a0weeks' gestation were manual removal of placenta and PPH. Severe maternal morbidity affected 1 in 81 women.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6241","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T05:04:59Z","timestamp":1664168699000},"page":"1562-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Medical termination of pregnancy for fetal anomaly at or beyond 20\u00a0weeks' gestation\u2014What are the maternal risks?"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8142-423X","authenticated-orcid":false,"given":"Bridie","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Maternal Fetal Medicine Royal Women's Hospital  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5172-3263","authenticated-orcid":false,"given":"Stefan C.","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-9191","authenticated-orcid":false,"given":"Julia","family":"Unterscheider","sequence":"additional","affiliation":[{"name":"Department of Maternal Fetal Medicine Royal Women's Hospital  Parkville Victoria Australia"},{"name":"Department of Obstetrics and Gynaecology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Abortion Statistics, England and Wales","author":"Department of Health United Kingdom","year":"2020"},{"key":"e_1_2_10_3_1","unstructured":"Royal College of Obstetricians and Gynaecologists.Termination of Pregnancy for Fetal Abnormality in England Scotland and Wales;2010."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.02.005"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12648"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479\u2010828x.2009.01117.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12168"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479\u2010828x.2006.00673.x"},{"key":"e_1_2_10_9_1","article-title":"Severe maternal morbidity; screening and review","author":"Kilpatrick S","year":"2016","journal-title":"Am Coll Obstet Gynaecol Soc Matern Fetal Med"},{"key":"e_1_2_10_10_1","unstructured":"Stillbirth Centre of Research Excellence and Perinatal Society of Australia and New Zealand (PSANZ).Clinical Practice Guideline for Care Around Stillbirth and Neonatal Death\u2014Section 7: The PSANZ Classification System for Stillbirths and Neonatal Deaths;2018."},{"key":"e_1_2_10_11_1","volume-title":"Confidential Audit of Severe Maternal Morbidity (SMM) in Ireland 2021 Form","author":"National Perinatology Epidemiology Centre","year":"2021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.044"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978\u2010018\u20100527\u20102"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.15306"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.6241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:11:46Z","timestamp":1692670306000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,2]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/pd.6241"],"URL":"https:\/\/doi.org\/10.1002\/pd.6241","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,2]]},"assertion":[{"value":"2022-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}