{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T22:46:18Z","timestamp":1776465978025,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objectives of this study were to investigate recent trends in non\u2010invasive prenatal testing (NIPT) utilisation, including factors associated with geographical variation, and to determine whether maternal or regional characteristics are associated with uptake the of NIPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included pregnant individuals in Ontario with an expected date of delivery from August 1st, 2016 to March 31st, 2020. Modified Poisson regression was used to estimate rate ratios for NIPT use adjusted for maternal and healthcare covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found substantial variation in NIPT uptake between regions within the province. The highest uptake was found in urban areas, highest quintile of neighbourhood income and education, for those who were \u226540\u00a0years of age and had a history of previous aneuploidy, for those with a prenatal care visit in the first trimester, multiple pregnancy, multigravidity and body mass index within the normal range (18.5\u201324.9\u00a0kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated significant regional and maternal differences in NIPT uptake across Ontario. Given the large sample size and diverse population, our study may have implications for other jurisdictions with large, socio\u2010demographically and geographically diverse populations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6257","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T09:00:53Z","timestamp":1667206853000},"page":"1594-1605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of maternal and geographical factors on the uptake of non\u2010invasive prenatal testing: A retrospective cohort study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0556-8087","authenticated-orcid":false,"given":"Ama Adutwumwaa","family":"Tweneboa Kodua","sequence":"first","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deshayne Blayre","family":"Fell","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"},{"name":"Children's Hospital of Eastern Ontario (CHEO) Research Institute  Ottawa Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences (ICES)  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Armour","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario (CHEO) Research Institute  Ottawa Ontario Canada"},{"name":"Better Outcomes Registry &amp; Network (BORN) Ontario  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley","family":"Dougan","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario (CHEO) Research Institute  Ottawa Ontario Canada"},{"name":"Better Outcomes Registry &amp; Network (BORN) Ontario  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara","family":"Bellai\u2010Dussault","sequence":"additional","affiliation":[{"name":"Children's Hospital of Eastern Ontario (CHEO) Research Institute  Ottawa Ontario Canada"},{"name":"Better Outcomes Registry &amp; Network (BORN) Ontario  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Little","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health University of Ottawa  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijwh.s67124"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008704"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13039\u2010019\u20100441\u20105"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010018\u20102168\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.10.005"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16837.1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20180046"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5563"},{"key":"e_1_2_9_10_1","article-title":"Health Quality Ontario. 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