{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:31:39Z","timestamp":1768293099222,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess patients' and embryonic characteristics that may have an influence on the decision to transfer a mosaic embryo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Single centre retrospective cohort study including 1247 PGT\u2010A cycles. Demographic and clinical factors associated with a decision to transfer a mosaic embryo were studied. Female age, number of previous cycles, previous availability of euploid embryos, history of miscarriages and parity as well as percentage of mosaicism, type of anomaly and chromosome risk were studied in relation to decision\u2010making. Outcomes after mosaic embryo transfer were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>To date, in 7.9% of cycles (99\/1247), patients have had to make a decision on the fate of their mosaic embryos. In 23.2% of cycles (23\/99), patients decided to transfer. In most cases (79.8%; 79\/99), patients underwent genetic counselling before the decision. None of the variables analysed were associated with the patients' decision, although parity and the high\u2010degree mosaicism (&gt;50%) seemed to be negatively associated with the decision to transfer (18.2% vs. 29.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.294; 10% vs. 32.2%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.052).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Neither reproductive history nor information on mosaic embryo characteristics through counselling seems to be determinative for patients when deciding to transfer a mosaic embryo. Promising and increasing data on clinical outcomes after mosaic embryo transfer will be of utmost importance to soften risk perception regarding mosaic embryos and give a better, simplified and more evidence\u2010based counselling.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6267","type":"journal-article","created":{"date-parts":[[2022,11,13]],"date-time":"2022-11-13T05:24:20Z","timestamp":1668317060000},"page":"1650-1657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Do reproductive history and information given through genetic counselling influence patients' decisions on mosaic embryo transfer?"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-661X","authenticated-orcid":false,"given":"Lluc","family":"Coll","sequence":"first","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics, Gynaecology and Reproduction Dexeus Mujer Dexeus University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f2nica","family":"Parriego","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics, Gynaecology and Reproduction Dexeus Mujer Dexeus University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Palacios","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics, Gynaecology and Reproduction Dexeus Mujer Dexeus University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Garcia","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics, Gynaecology and Reproduction Dexeus Mujer Dexeus University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Boada","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics, Gynaecology and Reproduction Dexeus Mujer Dexeus University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Buenaventura","family":"Coroleu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics, Gynaecology and Reproduction Dexeus Mujer Dexeus University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos P.","family":"Polyzos","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit Department of Obstetrics, Gynaecology and Reproduction Dexeus Mujer Dexeus University Hospital  Barcelona Spain"},{"name":"Faculty of Medicine and Health Sciences Ghent University (UZ Gent)  Gent Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Vidal","sequence":"additional","affiliation":[{"name":"Unitat de Biologia Cel\u00b7lular Facultat de Bioci\u00e8ncies Universitat Aut\u00f2noma de Barcelona  Bellaterra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Veiga","sequence":"additional","affiliation":[{"name":"Stem Cell Bank Centre of Regenerative Medicine in Barcelona  L\u2019Hospitalet de Llobregat Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc1500421"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.08.017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2019.103741"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2017.09.025"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.10.019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.01.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2020.11.041"},{"key":"e_1_2_9_9_1","unstructured":"COGEN.CoGEN [WWW Document];2018. 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