{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:49:27Z","timestamp":1792162167165,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Many studies, largely from high\u2010income countries (HIC), have reported outcomes in babies with trisomy 18 (T18), with a paucity of data from Africa. Knowledge of outcomes is important in counselling women prenatally diagnosed with T18. We aimed to review all prenatally diagnosed cases of T18 between January 2006 and December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Demographic data, diagnosis, gestation and outcome data were obtained from the Astraia\u00ae database and patient files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 88 pregnant women of whom 46 terminated their pregnancies (30 beyond 24\u00a0weeks' gestation). Three underwent foeticides, one had a caesarean section for maternal obstetric reasons and 26 underwent inductions of labour without foetal monitoring. Four neonates were live born but none lived &gt;8\u00a0h. In those who continued their pregnancies, the mean gestation at delivery was 34.8\u00a0weeks, 14 (33%) were live births and only 5 survived for &gt;24\u00a0h with none surviving to 1\u00a0year of life.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort, infants with T18 had lower live birth rates and shorter survival than in the current literature from HIC. This may be due to the implementation of non\u2010aggressive intrapartum care and comfort care for the neonates. This has implications for counselling in our setting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6270","type":"journal-article","created":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T07:43:20Z","timestamp":1668930200000},"page":"1643-1649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Survival rates and outcomes of pregnancies with prenatal diagnosis of trisomy 18: A 16\u2010year experience from a public hospital in South Africa"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8168-471X","authenticated-orcid":false,"given":"Chantal","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Groote Schuur Hospital and University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atta","family":"Owusu\u2010Bempah","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Groote Schuur Hospital and University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Boutall","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Groote Schuur Hospital and University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Groote Schuur Hospital and University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina\u2010Mari\u00e9","family":"Wessels","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Pathology University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Fieggen","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Department of Medicine Groote Schuur Hospital and University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.75.1.f38"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100004.1985.tb00184.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.10.1035"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32200"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767051003758879"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32220"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1243"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119432692.ch58"},{"key":"e_1_2_10_10_1","volume-title":"Edwards Syndrome","author":"Balasundaram P","year":"2022"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31382"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20107\u201081"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.777"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31173"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61365"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37495"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.9819"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102393\u201013\u2010209"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678\u20104685\u2010gmb\u20102018\u20100099"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34284"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61146"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35990"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102011\u2010301589"},{"key":"e_1_2_10_24_1","first-page":"239","article-title":"Characterisation of a 19\u2010year\u2010old survivor with Edwards syndrome","volume":"14","author":"Petek E","year":"2003","journal-title":"Genet Counsel"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina55070352"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11121466"},{"key":"e_1_2_10_27_1","unstructured":"Choice on Termination of Pregnancy Act No 92 of 1996.https:\/\/www.gov.za\/documents\/choice\u2010termination\u2010pregnancy\u2010act. 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