{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:14:00Z","timestamp":1773249240140,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a realistic simulation model for laparotomy\u2010assisted fetoscopic spina bifida aperta (SBa) surgery, to be used for training purposes and preoperative planning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The predefined general requirement was a realistic model of an exteriorized uterus, allowing all neurosurgical steps of the intervention. The uterus was modelled using ultrasound and MRI images of a 25 weeks\u2019 gravid uterus, consisting of flexible polyurethane foam coated with pigmented silicone. The fetal model, contained an opening on the dorsal side for a customizable spinal insert with all the aspects of a SBa, including a cele, placode, and myofascial and skin layer. The model was assessed in a series of validation experiments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Production costs are low, uterus and fetus are reusable. Placental localization and the level and size of the spinal defect are adjustable, enabling case\u2010specific adaptations. All aspects of the simulator were scored close to realistic or higher for both appearance and functional capacities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This innovative model provides an excellent training opportunity for centers that are starting a fetoscopic SBa repair program. It is the first simulation model with adjustable spinal defect and placental localisation. Further objective validation is required, but the potential for using this model in preoperative planning is promising.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6308","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T03:59:25Z","timestamp":1673409565000},"page":"355-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Development of a simulator for training of fetoscopic myelomeningocele surgery"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-4775","authenticated-orcid":false,"given":"Jochem K. H.","family":"Spoor","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lis","family":"van Gastel","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology Division of Obstetrics and Fetal Medicine Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Tahib","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"van Grieken","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willem","family":"van Weteringen","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Surgery Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Sterke","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Surgery Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"},{"name":"Department of Biomechanical Engineering Delft University of Technology  Delft The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet A.","family":"Baschat","sequence":"additional","affiliation":[{"name":"The Johns Hopkins Center for Fetal Therapy Department of Gynecology &amp; Obstetrics Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jena L.","family":"Miller","sequence":"additional","affiliation":[{"name":"The Johns Hopkins Center for Fetal Therapy Department of Gynecology &amp; Obstetrics Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tjeerd H. R.","family":"de Jong","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9 M. H.","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Departments of Pediatric Surgery Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex E.","family":"Eggink","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology Division of Obstetrics and Fetal Medicine Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4457-0940","authenticated-orcid":false,"given":"Philip L. J.","family":"DeKoninck","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynaecology Division of Obstetrics and Fetal Medicine Erasmus MC Sophia Children's Hospital University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1014379"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/UOG.20389"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/UOG.20389"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002406"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/UOG.18891"},{"key":"e_1_2_5_7_1","unstructured":"LeBouthillierF PapannaR.Fetal model developed for experimental spina bifida surgery. Accessed 31 May 2022.https:\/\/www.surgicaltouch.com\/copy\u2010of\u2010c"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485655"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41598\u2010021\u201085607\u20106"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.6308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T03:06:59Z","timestamp":1692587219000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/pd.6308"],"URL":"https:\/\/doi.org\/10.1002\/pd.6308","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,2]]},"assertion":[{"value":"2022-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}