{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:24:29Z","timestamp":1792275869457,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the prenatal ultrasound (US) findings, genetic results, and clinical outcomes of fetuses with suspected agenesis of the septum pellucidum (ASP) in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective, single\u2010center study included a cohort of fetuses with ASP diagnosed by prenatal imaging over a 10\u2010year period. We evaluated US findings, associated anomalies, genetic results, and clinical outcomes. Prenatal and postnatal imaging findings were compared as well as the clinical outcome of delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety patients were included, with a median follow\u2010up time of 36\u00a0months (1\u201396\u00a0months). Thirty\u2010six fetuses (40%) with isolated ASP were diagnosed by prenatal US or magnetic resonance imaging (MRI); 39 cases (43.3%) had ASP with central nervous system malformations and 15 cases (16.6%) had ASP with non\u2010CNS abnormalities. Additional imaging findings were supplemented with prenatal MRI in 13 cases. Genetic tests were performed on 32 patients, of whom six had abnormalities. Prenatal US results of 40 patients (40\/70) diagnosed by referral hospitals did not correspond to our findings. Of the 38 patients with postnatal records, 11 had abnormal neurological development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion(s)<\/jats:title><jats:p>The outcome of an isolated ASP is usually favorable; however, neurological developmental delay is commonly observed if it is combined with other malformations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6316","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T04:33:36Z","timestamp":1674275616000},"page":"763-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fetal agenesis of the septum pellucidum: Ultrasonic diagnosis and clinical significance"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8714-7050","authenticated-orcid":false,"given":"Xueyi","family":"Hu","sequence":"first","affiliation":[{"name":"ultrasound Department Guangdong Women and Children Hospital  Guangzhou China"},{"name":"Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Shang","sequence":"additional","affiliation":[{"name":"ultrasound Department Guangdong Women and Children Hospital  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1994.tb11888.x"},{"key":"e_1_2_10_3_1","first-page":"989","article-title":"The septum pellucidum: normal and abnormal","volume":"10","author":"Sarwar M","year":"1989","journal-title":"AJNR Am J\u00a0Neuroradiol"},{"key":"e_1_2_10_4_1","first-page":"299","volume-title":"Handbook of clinical neurology, vol. 30. 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Agenesis of the septum lucidum with malformation of the optic tract","volume":"77","author":"DE Morsier G","year":"1956","journal-title":"Schweiz Arch Neurol Psychiatr"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22018"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5663"},{"key":"e_1_2_10_9_1","article-title":"Prenatal diagnosis and outcome of fetuses with isolated agenesis of septum pellucidum: cohort study and meta\u2010analysis","author":"Di Pasquo E","year":"2021","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2628"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5247"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073818783460"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.04.039"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.10.4434"},{"key":"e_1_2_10_15_1","first-page":"481","article-title":"Septum pellucidum and cacum pellucid septum","volume":"16","author":"Li S","year":"2019","journal-title":"Chin J Med Ultrasound"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11206"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.152.2.353"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010004\u20101378\u20102"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.22373"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(16)31723\u20108"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.6316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T07:05:53Z","timestamp":1704870353000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1002\/pd.6316"],"URL":"https:\/\/doi.org\/10.1002\/pd.6316","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,29]]},"assertion":[{"value":"2022-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}