{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:00:35Z","timestamp":1765382435052,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fetal surgery has improved neonatal outcomes; however, it is unknown if the intervention contributes to the developmental of inflammatory pathologies in the placenta. Here, an association between fetal surgery and placental pathology was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This case\u2010control study compared pregnancies with fetal surgery (<jats:italic>n<\/jats:italic>\u00a0=\u00a022), pregnancies with an indication for fetal surgery but without an intervention being done (<jats:italic>n<\/jats:italic>\u00a0=\u00a013), and gestational\u2010age and fetus\u2010number matched controls (<jats:italic>n<\/jats:italic>\u00a0=\u00a036). Data on maternal, infant, and placental outcomes were abstracted. Additionally, immunohistochemistry identified expression of lymphoid and myeloid cells in the placenta on a subset of cases. Comparisons were performed using Kruskal\u2010Wallis or Pearson's chi\u2010squared tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal characteristics were comparable between groups. Most fetal interventions were for diaphragmatic hernia, spina bifida, or twin\u2010to\u2010twin transfusion syndrome. Fetuses who were operated on before birth were more likely to be born preterm (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). There was no increase in the rate of observed placental pathologies or immune cell infiltration in fetal surgery cases compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The data suggest that fetal surgery is not associated with increased inflammatory or morphologic pathology in the placenta. This observation supports the growing field of fetal surgery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6319","type":"journal-article","created":{"date-parts":[[2023,1,23]],"date-time":"2023-01-23T12:15:00Z","timestamp":1674476100000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fetal surgery is not associated with increased inflammatory placental pathology"],"prefix":"10.1002","volume":"43","author":[{"given":"Maria C.","family":"Cardenas","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Heidi","family":"Cheek\u2010Norgan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan E.","family":"Branda","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P.","family":"Norgan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro H.","family":"Schenone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen A.","family":"Lemens","sequence":"additional","affiliation":[{"name":"Department of Obstetrics 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