{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:28:46Z","timestamp":1792308526704,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["543002001"],"award-info":[{"award-number":["543002001"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Netherlands and Belgium have been among the first countries to offer non\u2010invasive prenatal testing (NIPT) as a first\u2010tier screening test. Despite similarities, differences exist in counseling modalities and test uptake. This study explored decision\u2010making and perspectives of pregnant women who opted for NIPT in both countries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A questionnaire study was performed among pregnant women in the Netherlands (NL) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0587) and Belgium (BE) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0444) opting for NIPT, including measures on informed choice, personal and societal perspectives on trisomy 21, 18 and 13 and pregnancy termination.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Differences between Dutch and Belgian women were shown in the level of informed choice (NL: 83% vs. BE: 59%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), intention to terminate the pregnancy in case of confirmed trisomy 21 (NL: 51% vs. BE: 62%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.003) and trisomy 13\/18 (NL: 80% vs. BE: 73%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.020). More Belgian women considered trisomy 21 a severe condition (NL: 64% vs. BE: 81%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Belgian women more frequently indicated that they believed parents are judged for having a child with trisomy 21 (BE: 42% vs. NL: 16%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and were less positive about quality of care and support for children with trisomy 21 (BE: 23% vs. NL: 62%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Differences in women's decision\u2010making regarding NIPT and the conditions screened for may be influenced by counseling aspects and country\u2010specific societal and cultural contexts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6329","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:19:11Z","timestamp":1675642751000},"page":"294-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A cross\u2010country comparison of pregnant women's decision\u2010making and perspectives when opting for non\u2010invasive prenatal testing in the Netherlands and Belgium"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-221X","authenticated-orcid":false,"given":"Lore","family":"Lannoo","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Fetomaternal Medicine University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Development and Regeneration Cluster Woman and Child Biomedical Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1801-588X","authenticated-orcid":false,"given":"Karuna R. M.","family":"van der Meij","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam UMC, location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille N.","family":"Bekker","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Utrecht University Medical Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"De Catte","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Fetomaternal Medicine University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Deckers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Fetomaternal Medicine University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koenraad","family":"Devriendt","sequence":"additional","affiliation":[{"name":"Department of Human Genetics University Hospitals Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nele","family":"Roggen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology AZ Imelda  Bonheiden Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u2010Jan H.","family":"Galjaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Gitsels\u2010van der Wal","sequence":"additional","affiliation":[{"name":"Department of Midwifery Science Amsterdam UMC, location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Public Health Research Institute Quality of Care  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-2234","authenticated-orcid":false,"given":"Merryn V. E.","family":"Macville","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics GROW School for Oncology and Reproduction Maastricht University Medical Center+  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Midwifery Science Amsterdam UMC, location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Midwifery Academy Amsterdam Groningen InHolland  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7187-4563","authenticated-orcid":false,"given":"Erik A.","family":"Sistermans","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam UMC, location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2438-6783","authenticated-orcid":false,"given":"Kristel","family":"Van Calsteren","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Fetomaternal Medicine University Hospitals Leuven  Leuven Belgium"},{"name":"Department of Development and Regeneration Cluster Woman and Child Biomedical Sciences KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Van Keirsbilck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology AZ Sint Jan  Bruges Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-0874","authenticated-orcid":false,"given":"Neeltje","family":"Crombag","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration Cluster Woman and Child Biomedical Sciences KU Leuven  Leuven Belgium"},{"name":"Department of Obstetrics and Gynaecology Utrecht University Medical Center  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3531-0597","authenticated-orcid":false,"given":"Lidewij","family":"Henneman","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Amsterdam UMC, location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Reproduction and Development Research Institute Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(97)02174\u20100"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17484"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c7401"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010genom\u2010083118\u2010015053"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13841"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/medethics\u20102019\u2010105675"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2922"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038154"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.11.041"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5053"},{"key":"e_1_2_9_12_1","unstructured":"Belgian Advisory Committee on Bioethics.Opinion no. 66 of 9 May 2016 on the ethical challenges posed by non\u2010invasive prenatal testing (NIPT) for trisomies 21 13 and 18.\u00a0Accessed September 1 2022.https:\/\/www.health.belgium.be\/en\/opinion\u2010no\u201066\u2010non\u2010invasive\u2010prenatal\u2010testing\u2010nipt"},{"key":"e_1_2_9_13_1","unstructured":"Belgian Advisory Committee on Bioethics.Advise nr 76 \u2010 advise on desirability of communicating numerical aberrations of the sex chromosomes detected by NIPT.\u00a0Accessed September 1 2022.\u00a0https:\/\/www.health.belgium.be\/en\/node\/39210"},{"key":"e_1_2_9_14_1","unstructured":"Health Council of the Netherlands. 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