{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:27:01Z","timestamp":1770740821429,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate fetal brain development using MRI (magnetic resonance imaging) in CDH (congenital diaphragmatic hernia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>52 isolated left CDH and 104 control fetuses were imaged using MRI. Brain morphometry (Biparietal diameter\u2014BPD, brain fronto\u2010occipital diameter\u2014BFOD, third ventricle, posterior ventricles, transcerebellar diameter\u2014TCD, anteroposterior and craniocaudal cerebellar vermis diameter\u2014AP and CC) and cortical structures (bilateral cingulate fissure\u2014CF, insular fissure\u2014IF, insular depth \u2010 ID) were compared with controls using Mann\u2013Whitney test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median gestational age at MRI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.95)and the median biparietal diameter (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.737) were comparable. Among morphometric parameters, only the brain fronto\u2010occipital diameter was significantly smaller in CDH (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001) and the third ventricle was significantly greater in CDH (&lt;0.0001). Among cortical structures, the cingulate and insular fissures were significantly deeper in CDH fetuses (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) as the insular depth ID was smaller in CDH (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CDH fetuses have a smaller fronto\u2010occipital diameter, reduced insular depth, deeper cingulate and insular fissure, and greater third ventricle width as compared to controls. These findings suggest that left CDH may have an impact on fetal brain development with an overall reduction in brain volume.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6368","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T23:13:40Z","timestamp":1683760420000},"page":"1002-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Brain cortical assessment by MRI in fetuses with left congenital diaphragmatic hernia"],"prefix":"10.1002","volume":"43","author":[{"given":"Isabella","family":"Fabietti","sequence":"first","affiliation":[{"name":"Fetal and Perinatal Medicine and Surgery Unit Medical and Surgical Department of the Fetus\u2010newborn\u2010infant Bambino Ges\u00f9 Children's Hospital IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Grassini","sequence":"additional","affiliation":[{"name":"Fetal and Perinatal Medicine and 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