{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:00:22Z","timestamp":1788789622864,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,6,14]],"date-time":"2023-06-14T00:00:00Z","timestamp":1686700800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Traditional obstetric practice relies upon history\u2010based assessment to screen for preeclampsia and guide preventative therapies but is hampered by low sensitivity, high false\u2010positive rates and low treatment rates. First\u2010trimester screening algorithms represent the most efficacious approach for risk prediction and could target early initiation of aspirin to well\u2010defined high\u2010risk populations. A large randomised controlled trial has demonstrated the clinical benefits of this approach, but widespread practice implementation has remained elusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a systematic review and meta\u2010analysis summarising studies linking first\u2010trimester preeclampsia screening algorithms with the initiation of preventative therapy and examined their effect on pre\u2010term preeclampsia rates compared with standard maternity care. Odds ratios were calculated together with 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>7 studies with a total of 377,790 participants were included. Within singleton populations, early initiation of aspirin in response to a high\u2010risk screening algorithm result reduced the prevalence of pre\u2010term preeclampsia by 39% compared with routine antenatal care (odds ratio 0.61; 95% CI: 0.52\u20130.70). There were significant reductions in the prevalence of preeclampsia at &lt;32\u201334\u00a0weeks, preeclampsia at any gestation and stillbirth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>First\u2010trimester screening algorithms for preeclampsia aligned with early initiation of preventative therapy with aspirin reduce the prevalence of pre\u2010term preeclampsia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6394","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T03:51:02Z","timestamp":1686109862000},"page":"950-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Do first\u2010trimester screening algorithms for preeclampsia aligned to use of preventative therapies reduce the prevalence of pre\u2010term preeclampsia: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-0449","authenticated-orcid":false,"given":"Ailsa Borbolla","family":"Foster","sequence":"first","affiliation":[{"name":"Department of Maternal and Fetal Medicine John Hunter Hospital  Newcastle New South Wales Australia"},{"name":"Faculty of Medicine University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicity","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Maternal and Fetal Medicine John Hunter Hospital  Newcastle New South Wales Australia"},{"name":"Faculty of Medicine University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Hyett","sequence":"additional","affiliation":[{"name":"Ingham Institute for Applied Medical Research Liverpool Hospital  Liverpool New South Wales Australia"},{"name":"Deprtment of Obstetrics and Gynaecology Faculty of Medicine Western Sydney University  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2109523"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17370"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.14781"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1884"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17399"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.09.041"},{"key":"e_1_2_8_8_1","unstructured":"Hypertension in Pregnancy: Diagnosis and Management.2019."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003891"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60712-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.561"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.22749"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.04.040"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.30804"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12499"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490385"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.034"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338470"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.11.1087"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.01.020"},{"key":"e_1_2_8_21_1","unstructured":"HigginsJ ThomasJ ChandlerJ et\u00a0al.Cochrane Handbook for Systematic Reviews of Interventions Version 6.3;2022. 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