{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T08:53:54Z","timestamp":1784364834103,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the impact of amnioinfusion and other peri\u2010operative factors on pregnancy outcomes in the setting of Twin\u2010twin transfusion syndrome (TTTS) treated via fetoscopic laser photocoagulation (FLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective study of TTTS treated via FLP from 2010 to 2019. Pregnancies were grouped by amnioinfusion volume during FLP (&lt;1\u00a0L vs.\u00a0\u22651\u00a0L). The primary outcome was latency from surgery to delivery. An amnioinfusion statistic (AIstat) was created for each surgery based on the volume of fluid infused and removed and the preoperative deepest vertical pocket. Regression analysis was planned to assess the association of AIstat with latency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with amnioinfusion of \u22651\u00a0L at the time of FLP had decreased latency from surgery to delivery (61\u00a0\u00b1\u00a029.4 vs. 73\u00a0\u00b1\u00a028.8\u00a0days with amnioinfusion &lt;1\u00a0L, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and increased preterm prelabor rupture of membranes (PPROM) &lt;34\u00a0weeks (44.7% vs. 33.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.042). Amnioinfusion \u22651\u00a0L was associated with an increased risk of delivery &lt;32 weeks (aRR 2.6, 95% CI 1.5\u20134.5), 30 weeks (aRR 2.4, 95% CI 1.5\u20133.8), and 28\u00a0weeks (aRR 1.9, 95% CI 1.1\u20132.3). Cox\u2010proportional regression revealed that AIstat was inversely associated with latency (HR 1.1, 95% CI 1.1\u20131.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Amnioinfusion \u22651\u00a0L during FLP was associated with decreased latency after surgery and increased PPROM &lt;34\u00a0weeks.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6415","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T03:39:00Z","timestamp":1691552340000},"page":"1239-1246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of amnioinfusion volume at the time of surgery for twin\u2010twin transfusion syndrome and latency to delivery"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8001-1444","authenticated-orcid":false,"given":"Braxton","family":"Forde","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Fetal Care Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foong\u2010Yen","family":"Lim","sequence":"additional","affiliation":[{"name":"Fetal Care Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Division of General and Thoracic Surgery Department of Pediatric Surgery Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"McKinney","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Fetal Care Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira","family":"Habli","sequence":"additional","affiliation":[{"name":"Fetal Care Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology TriHealth Health System  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kara B.","family":"Markham","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Fetal Care Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallory","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Fetal Care Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology TriHealth Health System  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammy","family":"Tabbah","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology TriHealth Health System  Cincinnati Ohio USA"},{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology Riverside Methodist Hospital  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Oria","sequence":"additional","affiliation":[{"name":"Division of General and Thoracic Surgery Department of Pediatric Surgery Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Peiro","sequence":"additional","affiliation":[{"name":"Fetal Care Center Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Division of General and Thoracic Surgery Department of Pediatric Surgery Cincinnati Children's Hospital Medical Center  Cincinnati Ohio 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