{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:18:11Z","timestamp":1788887891885,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K23 HD079605"],"award-info":[{"award-number":["K23 HD079605"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001673","name":"Fondation J\u00e9r\u00f4me Lejeune","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001673","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess brain development in living fetuses with Down syndrome (DS) by biometric measurements on fetal brain magnetic resonance images (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We scanned 10 MRIs of fetuses with confirmed trisomy 21 at birth and 12 control fetal MRIs without any detected anomalies. Fetal brain MRIs were analyzed using 14 fetal brain and skull biometric parameters. We compared measures between DS and controls in both raw MRIs and motion\u2010corrected and anterior\u2010posterior commissure\u2010aligned images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the reconstructed images, the measured values of the height of the cerebellar vermis (HV) and anteroposterior diameter of the cerebellar vermis (APDV) were significantly smaller, and the anteroposterior diameter of the fourth ventricle (APDF) was significantly larger in fetuses with DS than controls. In the raw MRIs, the measured values of the right lateral ventricle were significantly larger in fetuses with DS than in controls. Logistic regression analyses revealed that a new parameter, the cerebellar\u2010to\u2010fourth\u2010ventricle ratio (i.e., (APDV * Height of the vermis)\/APDF), was significantly smaller in fetuses with DS than controls and was the most predictive to distinguish between fetuses with DS and controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study revealed that fetuses with DS have smaller cerebellums and larger fourth ventricles compared to the controls.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6436","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T09:52:32Z","timestamp":1694512352000},"page":"1450-1458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Biometric magnetic resonance imaging analysis of fetal brain development in Down syndrome"],"prefix":"10.1002","volume":"43","author":[{"given":"Rie","family":"Kitano","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Tsuchiura Kyodo General Hospital  Tsuchiura Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel","family":"Madan","sequence":"additional","affiliation":[{"name":"Radiology Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Mikami","sequence":"additional","affiliation":[{"name":"Department of Neurology Tufts Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeevi","family":"Madankumar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Long Island Jewish Medical Center  New Hyde Park New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-9882","authenticated-orcid":false,"given":"Brian G.","family":"Skotko","sequence":"additional","affiliation":[{"name":"Down Syndrome Program Division of Medical Genetics and Metabolism Department of Pediatrics Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Santoro","sequence":"additional","affiliation":[{"name":"Down Syndrome Program Division of Medical Genetics and Metabolism Department of Pediatrics Massachusetts General Hospital  Boston Massachusetts USA"},{"name":"Department of Pediatrics Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Ralston","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology The University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-5267","authenticated-orcid":false,"given":"Diana W.","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Section on Prenatal Genomics and Fetal Therapy Center for Precision Health Research National Human Genome Research Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-7062","authenticated-orcid":false,"given":"Tomo","family":"Tarui","sequence":"additional","affiliation":[{"name":"Mother Infant Research Institute Tufts Medical Center  Boston Massachusetts USA"},{"name":"Pediatric Neurology Hasbro Children's Hospital  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38402"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000190580.88391.9a"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750\u20103639.2007.00113.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.207.1.9530318"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.214.2.r00fe40533"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhz094"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.102139"},{"key":"e_1_2_9_11_1","unstructured":"YunHJ PerezJDR SosaP et\u00a0al.Regional Alterations in Cortical Sulcal Depth in Living Fetuses with Down Syndrome;2021. 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