{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:25:40Z","timestamp":1790735140777,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Giant omphaloceles (GO) have associated pulmonary hypoplasia and respiratory complications. Total lung volumes (TLV) on fetal MRI can prognosticate congenital diaphragmatic hernia outcomes; however, its applicability to GO is unknown. We hypothesize that late gestation TLV and observed\u2010to\u2010expected TLV (O\/E TLV) on fetal MRI correlate with postnatal pulmonary morbidity in GO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A single\u2010institution retrospective review of GO evaluated between 2012 and 2022 was performed. Fetal MRI TLV between 32 and 36\u00a0weeks' gestation and O\/E TLV throughout gestation were calculated and correlated with postnatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>86 fetuses with omphaloceles were evaluated; however, only 26 met strict inclusion criteria. MRIs occurred between 18 and 36\u00a0weeks' gestation. Those requiring delivery room intubation had significantly lower late gestation TLV and O\/E TLV. O\/E TLV predicted tracheostomy placement and survival. Neither TLV nor O\/E TLV predicted the length of hospitalization or supplemental oxygen after discharge. Three fetuses had a TLV less than 35\u00a0mL: one died of respiratory failure, and the other two required tracheostomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fetal MRI TLV measured between 32 and 36\u00a0weeks' gestation and O\/E TLV predict the need for delivery room intubation and tracheostomy. O\/E TLV correlated with survival. These data support fetal MRI as a prognostic tool to predict GO associated pulmonary morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6449","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T16:47:25Z","timestamp":1696870045000},"page":"1514-1519","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fetal lung volumes measured by MRI predict pulmonary morbidity among infants with giant omphaloceles"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-8481","authenticated-orcid":false,"given":"Lauren T.","family":"Gallagher","sequence":"first","affiliation":[{"name":"Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey D.","family":"Lyttle","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana L.","family":"Meyers","sequence":"additional","affiliation":[{"name":"Colorado Institute for Maternal and Fetal Health  Aurora Colorado USA"},{"name":"Department of Radiology University of Colorado Denver School of Medicine  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gien","sequence":"additional","affiliation":[{"name":"Colorado Institute for Maternal and Fetal Health  Aurora Colorado USA"},{"name":"Department of Pediatrics University Colorado Denver  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Zaretsky","sequence":"additional","affiliation":[{"name":"Colorado Institute for Maternal and Fetal Health  Aurora Colorado USA"},{"name":"Department of Obstetrics and Gynecology University Colorado Denver  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry L.","family":"Galan","sequence":"additional","affiliation":[{"name":"Colorado Institute for Maternal and Fetal Health  Aurora Colorado USA"},{"name":"Department of Obstetrics and Gynecology University Colorado Denver  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Behrendt","sequence":"additional","affiliation":[{"name":"Colorado Institute for Maternal and Fetal Health  Aurora Colorado USA"},{"name":"Department of Obstetrics and Gynecology University Colorado Denver  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth W.","family":"Liechty","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Colorado Institute for Maternal and Fetal Health  Aurora Colorado USA"},{"name":"Department of Pediatric Surgery Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Pediatric Surgery University of Arizona  Tucson Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarkis Christopher","family":"Derderian","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Colorado Institute for Maternal and Fetal Health  Aurora Colorado USA"},{"name":"Department of Pediatric Surgery Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109610(82)90544\u2010x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.04.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.894"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.06.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010007\u20102034\u20103"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2017.03.023"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6040"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.17.19469"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.10.009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.02.060"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103468(96)90093\u20107"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6141"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.10.031"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.09.016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20103468(96)90671\u20105"}],"container-title":["Prenatal 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