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MEDLINE, EMBASE, Web of Science, MedRxiv and GreyLit were searched from 01\/2010\u201002\/2023 for studies reporting on the yield of PES over CMA or karyotype in fetuses with UTMs. Pooled incremental yield was determined using a random effects model. PROSPERO CRD42023364544.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen studies (410 cases) were included. The incremental yield for multisystem UTMs, any isolated UTMs, and BEKs was 31% [95% CI, 18%\u201346%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a078%], 16% [95% CI, 6%\u201326%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a080%] and 51% [95% CI, 27%\u201375%; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a034%]. The most common clinical diseases and syndromes identified, based on the variant genes detected, were Bardet\u2010Biedl syndrome (<jats:italic>BBS<\/jats:italic> genes), dominant and recessive polycystic kidney diseases (<jats:italic>PKD1<\/jats:italic>, <jats:italic>PKD2<\/jats:italic> and <jats:italic>PKHD1<\/jats:italic>) and renal cysts and diabetes syndrome (<jats:italic>HNF1B<\/jats:italic>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a notable incremental genetic diagnostic yield when PES was applied to multisystem UTMs and BEKs. There was a modest incremental yield when this technique was used for UTMs other than BEKs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6479","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T14:02:50Z","timestamp":1701957770000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["When should we offer antenatal sequencing for urinary tract malformations? 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