{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:05:02Z","timestamp":1763366702071},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2003,7,8]],"date-time":"2003-07-08T00:00:00Z","timestamp":1057622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Alteration of mid\u2010gestation serum markers in assisted\u2010conception pregnancies is believed to be attributable to ovarian superovulation treatment modalities. We compared alpha\u2010fetoprotein (AFP), human chorionic gonadotrophin (hCG), and unconjugated estriol (uE<jats:sub>3<\/jats:sub>) in two groups of unstimulated assisted\u2010conception pregnancies, that is, own\u2010oocyte frozen embryos (own\u2010FET) versus oocyte\u2010donated (OD) embryos.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010three OD\u2010conceived and 31 own\u2010FET\u2010conceived singleton parturient women (aged 29 \u00b1 4 years and 31 \u00b1 4 years respectively, <jats:italic>P<\/jats:italic> &lt; 0.05) were followed from embryo transfer throughout pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The daily pattern of first\u2010trimester serum \u03b2\u2010hCG was similar in both groups. The OD group had only significantly increased AFP concentrations compared to the own\u2010FET group (1.38 vs 0.99 median MoM respectively, <jats:italic>P<\/jats:italic> = 0.002). Although there were no chromosomal abnormalities and no fetal or neonatal deaths in either group, 12% OD women and 6.5% own\u2010FET women were found screen\u2010positive. Eight OD women and 11 FET women had an adverse obstetric outcome (<jats:italic>P<\/jats:italic> = NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OD embryos are a unique clinical model for evaluating the uterine compartment and its contribution to mid\u2010gestation serum marker secretion. Copyright \u00a9 2003 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.650","type":"journal-article","created":{"date-parts":[[2003,8,7]],"date-time":"2003-08-07T15:43:47Z","timestamp":1060271027000},"page":"625-628","source":"Crossref","is-referenced-by-count":14,"title":["Mid\u2010gestation Down syndrome screening test and pregnancy outcome among unstimulated assisted\u2010conception pregnancies"],"prefix":"10.1002","volume":"23","author":[{"given":"Adrian","family":"Shulman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Maymon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,7,8]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199612)16:12<1111::AID-PD998>3.0.CO;2-X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(98)80143-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/10641950109152646"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199607)16:7<635::AID-PD923>3.0.CO;2-V"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg153"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61819-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.4.691"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(200002)20:2<96::AID-PD766>3.0.CO;2-#"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.3.794"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.481"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970151012"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.10.2493"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/096914139700400402"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199608)16:8<699::AID-PD919>3.0.CO;2-P"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70334-0"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fpd.650","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:07:31Z","timestamp":1700276851000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8]]}},"alternative-id":["10.1002\/pd.650"],"URL":"https:\/\/doi.org\/10.1002\/pd.650","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,8]]}}}