{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:10:27Z","timestamp":1787771427751,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the prevalence of abnormalities of the corpus callosum (AbnCC) in a non\u2010selected population, to propose a systematic screening protocol for AbnCC in all populations through direct assessment, and to describe the follow\u2010up and prognosis of all AbnCC cases diagnosed in our clinical setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective review of the prevalence of AbnCC over 11\u00a0years. We included a sagittal assessment of the corpus callosum (CC) in the second\u2010trimester scan. AbnCC was classified into complete agenesis of CC (ACC) and dysgenesis of CC (DCC; including small, partial agenesis, thick and with lipoma).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 38,586 second\u2010trimester scans performed during our screening, 43 cases of AbnCC were detected (prevalence of 0.8\/1000). Of the AbnCC cases, 10 cases were identified as ACC (29.40%) and 24 as DCC (70.59%). Follow\u2010up investigations showed that in the 43 cases with AbnCC, 76.5% had other associated ultrasound abnormalities, 26.5% had genetic abnormalities, 11.8% had other MRI abnormalities, and 25% of the children had neurodevelopmental delays (8.8% of the total), which were severe in only one case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AbnCC is found in approximately 0.8\/1000 of cases in an unselected population. The findings suggest that systematic and direct assessment of the CC as part of screening ultrasound in the second trimester of gestation should be recommended as a routine practice.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6510","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T08:14:21Z","timestamp":1704096861000},"page":"1131-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of corpus callosum pathology in an unselected population. Should assessment of the corpus callosum be included in the routine 20\u00a0weeks scan?"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-4148","authenticated-orcid":false,"given":"M\u00aa Angeles","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics, Gynecology, and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Echevarr\u00eda","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics, Gynecology, and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perdomo","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics, Gynecology, and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"},{"name":"Obstetrics Service Department of Obstetrics, Gynecology and Reproductive Medicine Institut Universitari Quir\u00f3n Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"G\u00f3mez\u2010Chiari","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department Hospital Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Epidemiological Unit Department of Obstetrics, Gynecology, and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9216-9118","authenticated-orcid":false,"given":"Pilar","family":"Prats","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics, Gynecology, and Reproductive Medicine Institut Universitari Dexeus  Barcelona Spain"},{"name":"Obstetrics Service Department of Obstetrics, Gynecology and Reproductive Medicine Institut Universitari Quir\u00f3n Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Serra","sequence":"additional","affiliation":[{"name":"Obstetrics Service Department of Obstetrics, Gynecology and Reproductive Medicine Institut Universitari Quir\u00f3n Dexeus  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Albaiges","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics, Gynecology, and Reproductive Medicine Institut Universitari Dexeus  Barcelona 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