{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:40:27Z","timestamp":1775083227412,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["T002618N"],"award-info":[{"award-number":["T002618N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001279","name":"Great Ormond Street Hospital Charity","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001279","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the biomechanical properties of fetal preterm membranes (20\u00a0+\u00a00\u00a0weeks to 30\u00a0+\u00a00\u00a0weeks) to those of the term (37\u00a0+\u00a00 to 41\u00a0+\u00a00\u00a0weeks).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Amnion and chorion were manually separated and samples were cut to the required geometry. Rectangular samples with (mode 1) and without (uniaxial) a notch, were tested for tearing energy, critical elongation, and tangent stiffness. Suture retention and inter\u2010suture distance testing investigated the effect of suture placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the 15 preterm and 10 term placentas studied, no notable differences were observed in uniaxial testing. Mode 1 fracture testing showed a difference in tearing energy between the preterm and term chorion (0.025\u00a0\u00b1\u00a00.005 vs. 0.017\u00a0\u00b1\u00a00.005\u00a0J\/m<jats:sup>\u22121<\/jats:sup>; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027) but not in the amnion (0.030\u00a0\u00b1\u00a00.017 vs. 0.029\u00a0\u00b1\u00a00.009\u00a0J\/m<jats:sup>\u22121<\/jats:sup>; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.895). Both preterm amnion and chorion showed a higher critical elongation compared with term (1.229\u00a0\u00b1\u00a00.057 vs. 1.166\u00a0\u00b1\u00a00.046; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.019 and 1.307\u00a0\u00b1\u00a00.049 vs. 1.218\u00a0\u00b1\u00a00.058; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012). Preterm amnion had a higher suture retention strength than its term counterpart (0.189\u00a0\u00b1\u00a00.065 vs. 0.121\u00a0\u00b1\u00a00.031\u00a0N; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.023). In inter\u2010suture distance tests, no significant interaction was observed beyond 3\u00a0mm, but the preterm chorion showed less interaction at 1\u20132\u00a0mm distances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preterm membranes have equivalent or superior tensile properties to term membranes. The chorion appears to contribute to the mechanical integrity of fetal membranes, particularly in preterm stages.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6511","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T06:19:35Z","timestamp":1704262775000},"page":"317-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Preterm membranes are mechanically more resistant than term membranes"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-6434","authenticated-orcid":false,"given":"Simen","family":"Vergote","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology UZ Leuven Department of Development and Regeneration Cluster Woman and Child Group Biomedical Sciences KU Leuven  Leuven 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