{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:35:12Z","timestamp":1770813312507,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T00:00:00Z","timestamp":1705190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003976","name":"Israel National Institute for Health Policy Research","doi-asserted-by":"publisher","award":["2015\/82"],"award-info":[{"award-number":["2015\/82"]}],"id":[{"id":"10.13039\/501100003976","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chromosomal\u2010microarray\u2010analysis (CMA) may reveal susceptibility\u2010loci (SL) of varied penetrance for autism\u2010spectrum\u2010disorder (ASD) and other neurodevelopmental conditions. Attitudes of women\/parents to disclosure of SL during pregnancy are understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multiple\u2010choice questionnaire was distributed to postpartum women. Data were collected on women's interest to receive prenatal genetic information with various levels of penetrance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women's (<jats:italic>n<\/jats:italic>\u00a0=\u00a0941) disclosure choices were dependent on the magnitude of risk: approximately 70% supported disclosure of either full or 40% penetrance, 53% supported disclosure at a 20% risk threshold, and 40% supported disclosure at 10% or less. Although most women supported, rejected or were indecisive about disclosure consistently across all risk levels, nearly one\u2010quarter (24%) varied their responses based on penetrance, and this was associated with religiosity, education, parity and concern about fetal health (<jats:italic>p<\/jats:italic>\u2010values\u00a0&lt;0.04). Among those who varied their choices, the risk threshold was lower among secular women (20%) than among ultraorthodox women (40%). In a multivariable analysis, ultraorthodox women were much less likely to vary their choices on ASD disclosure compared with secular women (aOR\u00a0=\u00a00.37, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women's attitudes toward disclosure are influenced by the level of risk and their individual characteristics. We therefore encourage engaging women\/couples in disclosure decisions regarding uncertain and probabilistic results from prenatal genomic tests.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6518","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T05:20:05Z","timestamp":1705296005000},"page":"270-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Women's attitudes towards disclosure of genetic information in pregnancy with varying levels of penetrance"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-0434","authenticated-orcid":false,"given":"Vitalia","family":"Libman","sequence":"first","affiliation":[{"name":"Braun School of Public Health The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Macarov","sequence":"additional","affiliation":[{"name":"Department of Genetics Hadassah Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yechiel","family":"Friedlander","sequence":"additional","affiliation":[{"name":"Braun School of Public Health The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drorith","family":"Hochner\u2010Celnikier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah Medical Organization and Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishai","family":"Sompolinsky","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah Medical Organization and Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uri P.","family":"Dior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hadassah Medical Organization and Faculty of Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Osovsky","sequence":"additional","affiliation":[{"name":"Department of Neonatology Rabin Medical Center, Beilinson Hospital  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Basel\u2010Salmon","sequence":"additional","affiliation":[{"name":"The Raphael Recanati Genetics Institute Rabin Medical Center, Beilinson Hospital  Petah Tikva Israel"},{"name":"Felsenstein Medical Research Center  Petah Tikva Israel"},{"name":"Pediatric Genetics Unit Schneider Children Medical Center  Petah Tikva Israel"},{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Wiznitzer","sequence":"additional","affiliation":[{"name":"Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"The Helen Schneider Hospital for Women Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yehuda","family":"Neumark","sequence":"additional","affiliation":[{"name":"Braun School of Public Health The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vardiella","family":"Meiner","sequence":"additional","affiliation":[{"name":"Department of Genetics Hadassah Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayala","family":"Frumkin","sequence":"additional","affiliation":[{"name":"Department of Genetics Hadassah Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-2276","authenticated-orcid":false,"given":"Hagit","family":"Hochner","sequence":"additional","affiliation":[{"name":"Braun School of Public Health The Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiri","family":"Shkedi\u2010Rafid","sequence":"additional","affiliation":[{"name":"Department of Genetics Hadassah Medical Center  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5212"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17533"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.73"},{"key":"e_1_2_9_5_1","unstructured":"GardinerC WellesleyD KilbyMD et\u00a0al.Recommendations for the\u00a0Use of Chromosome Microarray in Pregnancy;2015. 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