{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T20:40:17Z","timestamp":1787344817707,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T00:00:00Z","timestamp":1708128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the diagnostic performance of postmortem ultrasound (PMUS), 9.4\u00a0T magnetic resonance imaging (MRI) and microfocus computed tomography (micro\u2010CT) for the examination of early gestation fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eight unselected fetuses (10\u201315\u00a0weeks gestational age) underwent at least 2 of the 3 listed imaging examinations. Six fetuses underwent 9.4\u00a0T MRI, four underwent micro\u2010CT and six underwent PMUS. All operators were blinded to clinical history. All imaging was reported according to a prespecified template assessing 36 anatomical structures, later grouped into five regions: brain, thorax, heart, abdomen and genito\u2010urinary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>More anatomical structures were seen on 9.4\u00a0T MRI and micro\u2010CT than with PMUS, with a combined frequency of identified structures of 91.9% and 69.7% versus 54.5% and 59.6 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) respectively according to comparison groups. In comparison with 9.4\u00a0T MRI, more structures were seen on micro\u2010CT (90.2% vs. 83.3%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Anatomical structures were described as abnormal on PMUS in 2.7%, 9.4\u00a0T MRI in 6.1% and micro\u2010CT 7.7% of all structures observed. However, the accuracy test could not be calculated because conventional autopsy was performed on 6 fetuses of that only one structure was abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Micro\u2010CT appears to offer the greatest potential as an imaging adjunct or non\u2010invasive alternative for conventional autopsies in early gestation fetuses.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6532","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T14:44:14Z","timestamp":1708181054000},"page":"572-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Postmortem imaging of fetuses at early gestations: A comparison of microfocus computed tomography with postmortem magnetic resonance at 9.4\u00a0T and postmortem ultrasound"],"prefix":"10.1002","volume":"44","author":[{"given":"Patricia","family":"Ibarra Vilar","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-342X","authenticated-orcid":false,"given":"Jacques C.","family":"Jani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9899-6851","authenticated-orcid":false,"given":"Mieke M.","family":"Cannie","sequence":"additional","affiliation":[{"name":"Department of Radiology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-9967","authenticated-orcid":false,"given":"Susan C.","family":"Shelmerdine","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8275-2761","authenticated-orcid":false,"given":"Sophie","family":"Lecomte","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-0611","authenticated-orcid":false,"given":"Marleen","family":"Verhoye","sequence":"additional","affiliation":[{"name":"Bio\u2010Imaging Lab University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1708-2634","authenticated-orcid":false,"given":"Ciaran J.","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1213-3516","authenticated-orcid":false,"given":"Owen J.","family":"Arthurs","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0679-4648","authenticated-orcid":false,"given":"Andrew","family":"Carlin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Brugmann Universit\u00e9 Libre de Bruxelles  Brussels 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