{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:11:02Z","timestamp":1792030262053,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T00:00:00Z","timestamp":1707609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate which cytogenetic characteristics of confined placental mosaicism (CPM) detected in the first trimester chorionic villi and\/or placentas in terms of chromosome aberration, cell lineage involved and trisomy origin will lead to fetal growth restriction and low birthweight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cohort study using routinely collected perinatal data and cytogenetic data of non\u2010invasive prenatal testing, the first trimester chorionic villi sampling and postnatal placentas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>215 CPM cases were found. Fetal growth restriction (FGR) and low birthweight below the 10<jats:sup>th<\/jats:sup> percentile (BW\u00a0&lt;\u00a0p10) were seen in 34.0% and 23.1%, respectively. Excluding cases of trisomy 16, 29.1% showed FGR and 17.9% had a BW\u00a0&lt;\u00a0p10. The highest rate of FGR and BW\u00a0&lt;\u00a0p10 was found in CPM type 3, but differences with type 1 and 2 were not significant. FGR and BW\u00a0&lt;\u00a0p10 were significantly more often observed in cases with meiotic trisomies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There is an association between CPM and FGR and BW\u00a0&lt;\u00a0p10. This association is not restricted to trisomy 16, neither to CPM type 3, nor to CPM involving a meiotic trisomy. Pregnancies with all CPM types and origins should be considered to be at increased risk of FGR and low BW\u00a0&lt;\u00a0p10. A close prenatal fetal monitoring is indicated in all cases of CPM.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6533","type":"journal-article","created":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T04:09:00Z","timestamp":1707710940000},"page":"289-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The role of confined placental mosaicism in fetal growth restriction: A retrospective cohort study"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-2529","authenticated-orcid":false,"given":"Geerke M.","family":"Eggenhuizen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attie T. J. 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