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We interviewed Black and Hispanic obstetric patients at a safety net clinic in Florida shortly after the state rolled out cfDNA as a first\u2010tier screening method for publicly insured patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Black and Hispanic patients receiving prenatal care from a prenatal or maternal fetal medicine clinic at a federally qualified health center in Jacksonville, FL were invited to participate in a qualitative interview in English or Spanish to explore experiences and perceptions of prenatal cfDNA screening. Participants were recruited following their first prenatal visit when cfDNA is typically introduced. Interview transcripts were qualitatively analyzed for iterative themes based on principles of grounded theory.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred Black and Hispanic patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a051 non\u2010Hispanic Black, <jats:italic>n<\/jats:italic>\u00a0=\u00a043 Hispanic, <jats:italic>n<\/jats:italic>\u00a0=\u00a03 Hispanic Black, <jats:italic>n<\/jats:italic>\u00a0=\u00a03 Not Reported\/Other) completed an interview. Participants described minimal opportunity for pre\u2010screening counseling and limited health literacy about cfDNA or its uses. Some believed that cfDNA could positively impact pregnancy health. Many were unsure if they had received cfDNA even though they were aware of the information provided by it. Most participants expressed an interest in cfDNA as a means for early detection of fetal sex and as an additional indication of general fetal health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patient experiences indicate limited informed consent and decision\u2010making for cfDNA, discordant with professional guidelines on pre\u2010screen counseling. Our findings suggest that there should be additional investment in implementing cfDNA in safety net settings to ensure that patients and providers receive the support necessary for effective patient counseling and follow\u2010on care for the ethical implementation of cfDNA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6541","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T03:17:31Z","timestamp":1709263051000},"page":"409-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patient experiences with prenatal cell\u2010free DNA screening in a safety net setting"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0127-9555","authenticated-orcid":false,"given":"Kirsten A.","family":"Riggan","sequence":"first","affiliation":[{"name":"Biomedical Ethics Research Program Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Barwise","sequence":"additional","affiliation":[{"name":"Biomedical Ethics Research Program Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Q.","family":"Yap","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niamh","family":"Condon","sequence":"additional","affiliation":[{"name":"Department of Maternal\u2010Fetal Medicine University of Florida Health  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6136-9256","authenticated-orcid":false,"given":"Megan A.","family":"Allyse","sequence":"additional","affiliation":[{"name":"Biomedical Ethics Research Program Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Obstetrics &amp; Gynecology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2023.100874"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004084"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.145"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687\u2010020\u201000498\u2010w"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6155"},{"key":"e_1_2_10_7_1","unstructured":"Coalition for access to prenatal screening. 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