{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:21:43Z","timestamp":1778923303376,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This aim of this study was to detail maternal and fetal anomalies observed on a national scale in a large French cohort of patients presenting high hCG values (\u226510 multiple of the median [MoM]) at Down syndrome screening in order to define clear and optimal guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective multicenter study based on a French annual database of all trisomy 21 screenings. Our study targeted and studied cases with hCG or hCG\u03b2 values \u226510 MoM. Complementary exams and outcomes were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The calculated frequency was 0.05% for hCG\u03b2 \u226510 MoM in unselected patients. For this series of 289 cases, a complication of the pregnancy or a poor outcome was observed in 145 cases (51%) as follows: 96 (66%) cases of fetal disease, 23 (16%) of maternal disease, 5 (3.5%) of placental anomalies and 21 (14.5%) of systemic disease concerning mother, fetus and placenta.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study establishes the frequency of hCG or hCG\u03b2 values \u226510 MoM, presents a flow chart that optimizes follow\u2010up, and gives clear information for patients presenting with such abnormal values at trisomy 21 screening.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6588","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T11:53:29Z","timestamp":1715946809000},"page":"959-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Very elevated hCG\u03b2 (\u226510 multiple of the median) in maternal marker screening for Down syndrome: Frequency, etiologies, outcomes, and guidelines"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1941-5516","authenticated-orcid":false,"given":"Sophie","family":"Dreux","sequence":"first","affiliation":[{"name":"Biochimie\u2010Hormonologie H\u00f4pital R. 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