{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T17:53:50Z","timestamp":1790272430989,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate maternal and perinatal outcomes following fetal intervention in the context of maternal \u201cmirror\u201d syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A multicenter retrospective study of all cases of fetal hydrops complicated by maternal \u201cmirror\u201d syndrome and treated by any form of fetal therapy between 1995 and 2022. Medical records and ultrasound images of all cases were reviewed. \u201cMirror\u201d syndrome was defined as fetal hydrops and\/or placentomegaly associated with the maternal development of pronounced edema, with or without pre\u2010eclampsia. Fetal hydrops was defined as the presence of abnormal fluid collections in \u22652 body cavities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one pregnancies met the inclusion criteria. Causes of fetal hydrops and\/or placentomegaly included fetal lung lesions (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), twin\u2010twin transfusion syndrome (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), severe fetal anemia (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), and others (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). Mean gestational age at \u201cmirror\u201d presentation was 27.0\u00a0\u00b1\u00a03.8\u00a0weeks. Maternal \u201cmirror\u201d syndrome was identified following fetal therapeutic intervention in 14 cases (66.6%). \u201cMirror\u201d symptoms resolved or significantly improved before delivery in 8 (38.1%) cases with a mean interval from fetal intervention to maternal recovery of 13.1\u00a0days (range 4\u201335). Three women needed to be delivered because of worsening \u201cmirror\u201d syndrome. Of the 21 pregnancies treated (27 fetuses), there were 15 (55.5%) livebirths, 7 (25.9%) neonatal deaths and 5 (18.5%) intra\u2010uterine deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Following successful treatment and resolution of fetal hydrops, maternal \u201cmirror\u201d syndrome can improve or sometimes completely resolve before delivery. Furthermore, the recognition that \u201cmirror\u201d syndrome may arise only after fetal intervention necessitates hightened patient maternal surveillance in cases of fetal hydrops.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6589","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T11:54:32Z","timestamp":1715860472000},"page":"979-987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Maternal \u201cmirror\u201d syndrome: Evaluating the benefits of fetal therapy"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-1167","authenticated-orcid":false,"given":"Joanna","family":"Sichitiu","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics &amp; Gynaecology Mount Sinai Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Ontario Fetal Centre  Toronto Ontario Canada"},{"name":"Woman\u2010Mother\u2010Child Department Lausanne University Hospital (CHUV)  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawaz","family":"Alkazaleh","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics &amp; 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