{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:10:10Z","timestamp":1775142610351,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6-7","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe and compare maternal and fetal comorbidities and obstetrical outcomes in pregnancies with hypoplastic left and right heart (HLHS and HRH) single ventricle cardiac defects (SVCD) from a single center under a multidisciplinary protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A single center retrospective review of fetal SVCD from 2013 to 2022. Maternal\u2010fetal comorbidities, delivery, and postnatal outcomes were compared between HLHS and HRH using descriptive statistics and univariate and multivariate analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 181 SVCD pregnancies (131 HLHS; 50 HRH), 9% underwent termination, 4% elected comfort care, 5 died in utero and 147\/152 liveborns survived to the first cardiac intervention. Cesarean delivery occurred in 57 cases (37%), planned in 36 and unplanned in 21. Comorbidities, which did not differ between HLHS and HRH, included fetal growth restriction (FGR, 17%), prematurity (14%), maternal hypertension (9%), maternal obesity (50%), fetal extracardiac anomalies and chromosome anomalies (12%, 13%). In multivariate analysis, only earlier gestational age at delivery and oligohydramnios predicted decreased odds of survival at one year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal\u2010fetal comorbidities are common in both HLHS and HRH. Earlier gestational age at delivery and oligohydramnios predict lower postnatal survival. FGR, even with severe early onset, did not significantly impact short\u2010 or long\u2010term neonatal survival in single ventricle conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6591","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T01:34:18Z","timestamp":1716514458000},"page":"783-795","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Maternal\u2010fetal comorbidities and obstetrical outcomes of fetal single ventricle cardiac defects: 10\u00a0years' experience with a multidisciplinary management protocol at a single center"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8540-1740","authenticated-orcid":false,"given":"Cynthie K.","family":"Wautlet","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha A.","family":"Kops","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori J.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Behrendt","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael V.","family":"Zaretsky","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina F.","family":"Cuneo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Pediatrics University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"},{"name":"Department of Obstetrics University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry L.","family":"Galan","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Department of Obstetrics and Gynecology University of Colorado School of Medicine, and Colorado Fetal Care Center Children's Hospital of Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23586"},{"key":"e_1_2_8_3_1","volume-title":"4.5 Hypoplastic Left Heart Syndrome","author":"CDC","year":"2021"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.118.010893"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13672"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2018.12.016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa117"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2017.01.056"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2022.07.055"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.04.061"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.020299"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15893"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(86)90773\u20108"},{"key":"e_1_2_8_15_1","unstructured":"Checklists.Strobe. 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