{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:02:04Z","timestamp":1770915724569,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"6-7","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine if the presence of fetal growth restriction (FGR) is associated with an increased risk of genetic abnormalities in the setting of congenital heart disease (CHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective cohort study involving pregnancies that met the following criteria: (i) prenatal diagnosis of CHD, (ii) singleton live\u2010birth, and (iii) genetic testing was performed either pre\u2010 or postnatally. Genetic results were reviewed by a clinical geneticist for updated variant classification. Fetal growth was stratified as appropriate for gestational age (AGA) or FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the total of 445 fetuses that met the study criteria, 325 (73.0%) were AGA and 120 (27.0%) were FGR. Genetic abnormalities were detected in 131 (29.4%) pregnancies. There was a higher rate of genetic abnormalities (36.7% vs. 26.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04), which was driven by aneuploidies (20.8% vs. 8.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.0006) in the FGR population. Early onset growth restriction was associated with a higher rate of genetic abnormalities (44.5% vs. 25.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03). The rate of genetic abnormalities was significantly higher in the shunt category as compared to remainder of the cardiac anomalies (62.5% in shunt lesions vs. 24.7%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.00001). The rates of FGR (40.9% vs. 21.4%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and genetic abnormalities (52% vs. 20.4%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) were significantly higher in the presence of extra\u2010cardiac anomalies (ECA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The presence of FGR in fetal CHD population was associated with underlying genetic abnormalities, specifically aneuploidies. Patients should be appropriately counseled regarding the higher likelihood of a genetic condition in the presence of FGR, early onset FGR, shunt lesions and ECA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6597","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T11:43:45Z","timestamp":1716896625000},"page":"879-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Is there an increased risk of genetic abnormalities in fetuses with congenital heart disease in the setting of growth restriction?"],"prefix":"10.1002","volume":"44","author":[{"given":"Kathleen","family":"Gianforcaro","sequence":"first","affiliation":[{"name":"Richard D. Wood Jr Center for Fetal Diagnosis &amp; Treatment Department of General, Thoracic &amp; Fetal Surgery Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Pilchman","sequence":"additional","affiliation":[{"name":"Richard D. Wood Jr Center for Fetal Diagnosis &amp; Treatment Department of General, Thoracic &amp; Fetal Surgery Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Conway","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie S.","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"Richard D. Wood Jr Center for Fetal Diagnosis &amp; Treatment Department of General, Thoracic &amp; Fetal Surgery Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Rychik","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3019-0031","authenticated-orcid":false,"given":"Shelly","family":"Soni","sequence":"additional","affiliation":[{"name":"Richard D. Wood Jr Center for Fetal Diagnosis &amp; Treatment Department of General, Thoracic &amp; Fetal Surgery Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.025"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1498"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9120879"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u20100791\u20108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.07.065"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.03.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102393\u201014\u201063"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109378(00)70513\u20108"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2015.1121480"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.597900"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2018.02.002"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6339"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.05.010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.1.1887021"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355525"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093056"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja12.10811"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.14209"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13774"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22072"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6115"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13081493"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2004.08.006"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6309"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010036"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.09.1358"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006\u20102742"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.82.1.83"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a115839"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.08.003"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2005.07.006"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(82)91571\u20109"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389202915666140716175634"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20761"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.183216"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6597","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T12:27:16Z","timestamp":1718540836000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6597"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":35,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/pd.6597"],"URL":"https:\/\/doi.org\/10.1002\/pd.6597","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]},"assertion":[{"value":"2024-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}