{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:28Z","timestamp":1786978288238,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Acute fetal leukemia is rare and characterized by a very poor prognosis. The aims of this study were to identify cases of acute fetal leukemia and to describe ultrasound and fetopathological findings that should lead to a suspicion of this diagnosis, as well as the investigations required to confirm it.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A national retrospective study was conducted. Clinical data, prenatal ultrasounds and postmortem findings of fetal acute leukemia cases were collected and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We collected seven cases: four in utero fetal deaths, two neonatal deaths and one termination of pregnancy. Prenatal ultrasounds showed fetal hydrops (42.9%) associated with hepatosplenomegaly (100%). In addition, post\u2010mortem examination (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a06) suggested a Down syndrome in one case and showed other organomegaly (83.3%) due to blastic infiltration, mainly in the liver, along with extrahepatic multivisceral hematopoiesis. Immunostainings allowed to specify the type of leukemia (71.4%). In one case, diagnosis was made on blood smear and flow cytometry was performed on fresh blood samples. All cases corresponded to acute myeloid leukemia. Karyotype was abnormal in 4 cases (66.7%), including one free trisomy 21, two mosaic trisomy 21 and one chromosome 15 deletion.\n                      <jats:italic>GATA1<\/jats:italic>\n                      gene mutations were identified in two cases: one mosaic trisomy 21 and one with normal karyotype.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Any hepatosplenomegaly associated with fetal hydrops and a negative immune, infectious, and metabolic work\u2010up, should suggest acute fetal leukemia and prompt additional investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6630","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T23:48:50Z","timestamp":1719359330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Acute fetal leukemia: When should it be suspected? What assessment should be performed? A case series and review of literature"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2536-7162","authenticated-orcid":false,"given":"Pierre\u2010Louis","family":"Forey","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University Hospital Grenoble\u2010Alpes  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1011-875X","authenticated-orcid":false,"given":"Maud","family":"Favier","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital Lyon  Bron France"},{"name":"SoFFoet Soci\u00e9t\u00e9 Fran\u00e7aise de F\u0153topathologie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Beneteau","sequence":"additional","affiliation":[{"name":"SoFFoet Soci\u00e9t\u00e9 Fran\u00e7aise de F\u0153topathologie  Paris France"},{"name":"Department of Medical Genetic University Hospital  Nantes 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