{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:59:43Z","timestamp":1789707583783,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T00:00:00Z","timestamp":1725667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To treat the fetus presenting with in\u00a0utero compromise due to a large vein of Galen malformation (VOGM) using glue embolization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The fetus that was referred for termination of pregnancy at 30\u00a0weeks of gestation due to severe cardiomegaly, mild pericardial effusion and large VOGM was evaluated using ultrasound. There was reversed end diastolic flow in the umbilical artery Doppler indicating imminent fetal demise in the premature fetus weighing &lt;1200\u00a0g. Considering the request of parents, a treatment similar to recently reported cases of VOGM embolization in\u00a0utero was attempted as an emergency procedure to salvage the baby. Due to unavailability of coils, financial constraints and urgent need for intervention, n\u2010butyl cyanoacrylate glue with lipiodol was used to embolize the venous outflow of VOGM outflow under ultrasonographic guidance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was immediate correction of the umbilical artery Doppler waveform with the establishment of a normal flow pattern. The cardiomegaly resolved over 3\u00a0weeks and fetal MRI done 2\u00a0weeks later showed normal brain architecture with no evidence of hemorrhage or infarction. Pregnancy was continued for 4\u00a0weeks after the procedure and terminated at 36\u00a0weeks. A female baby weighing 1900\u00a0g was delivered by Cesarean section with an Apgar of 8\/10. Though initially the baby did well, with mild ventriculomegaly reported on postnatal day 5, she eventually presented at 3\u00a0months of age with cardiac failure. As the MRI showed encephalomalacia, due to uncertainty of neurological outcome, further treatment was not pursued by the parents and the baby died a few days later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the first report on the use of glue to treat VOGM prenatally. Though technically successful in correcting the in\u00a0utero compromise, the baby eventually expired. Cases of in\u00a0utero embolization using coils and glue have shown success in reversing prenatal pathology and improving survival. However, long\u2010term outcomes including neurological status are yet to be reported.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6662","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T11:09:25Z","timestamp":1725707365000},"page":"1367-1371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reversal of Fetal Compromise Following In Utero Treatment of Vein of Galen Malformation Using Glue"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-0909","authenticated-orcid":false,"given":"Mamatha","family":"Gowda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jawaharlal Institute of Postgraduate Medical Education and Research, JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariharan","family":"Krishnaraj","sequence":"additional","affiliation":[{"name":"Department of Interventional Radiology JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugesan","family":"Ambalakkuthan","sequence":"additional","affiliation":[{"name":"Department of Neonatology JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6552-7225","authenticated-orcid":false,"given":"Navya","family":"Chinta","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jawaharlal Institute of Postgraduate Medical Education and Research, JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamil","family":"Selvan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics JIPMER  Puducherry India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6203"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.02.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.1878494"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.8.PEDS10231"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211752"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6585"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jvd2020018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.976060"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14401"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.11.1248"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.043421"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102021\u2010058147"},{"key":"e_1_2_8_14_1","unstructured":"D. B.Orbach \u201cVein of Galen: From Genomics to Treatment (FT\u2010INV\u20102)\u201d (invited lecture ISPD 24th International Conference on Prenatal Diagnosis and Treatment ISPD 2024 Boston on July 8 2024)."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41983\u2010024\u201000822\u2010y"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6662","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T14:39:20Z","timestamp":1728916760000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,7]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/pd.6662"],"URL":"https:\/\/doi.org\/10.1002\/pd.6662","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,7]]},"assertion":[{"value":"2024-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}