{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:49:20Z","timestamp":1792111760058,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Fetal two\u2010dimensional speckle tracking echocardiography (2D\u2010STE) is a novel technique that provides information on fetal heart function by measuring global longitudinal strain (GLS) and global longitudinal strain rate (GLSR). These features assess the longitudinal deformity of the fetal cardiac wall. 2D\u2010STE is shown to be of prognostic value in children and adults with congenital heart disease (CHD). Therefore, its importance in fetal life should also be considered. This systematic review and meta\u2010analysis provides an overview of the literature on 2D\u2010STE (GLS\/GLSR) in fetuses with CHD, focusing on the left and right ventricles (LV\/RV). Findings indicated that LV\u2010GLS was significantly lower in fetuses with coarctation of the aorta (CoA) and Tetralogy of Fallot (ToF) compared to controls. Conversely, fetuses with a single left ventricle exhibited higher LV\u2010GLS. RV\u2010GLS was significantly lower in fetuses with hypoplastic left heart syndrome (HLHS) and ToF compared to controls. LV\u2010GLSR was significantly lower in fetuses with CoA. Overall, considerable heterogeneity was observed, possibly due to differences in study design. More prospective longitudinal studies on 2D\u2010STE in fetuses with CHD, considering heterogeneity parameters, could offer better insights into this promising technique.<\/jats:p>","DOI":"10.1002\/pd.6672","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T04:07:07Z","timestamp":1728101227000},"page":"1479-1497","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Fetal Speckle Tracking Echocardiography Measured Global Longitudinal Strain and Strain Rate in Congenital Heart Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5301-3319","authenticated-orcid":false,"given":"Sarah","family":"van den Wildenberg","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Fetal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid M.","family":"van Beynum","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Cardiology Erasmus Medical Center Sophia's Children Hospital  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malou E. C.","family":"Havermans","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Fetal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Boersma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinical Epidemiology and Statistics Unit Thorax Center Cardiovascular Institute Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-572X","authenticated-orcid":false,"given":"Greggory R.","family":"DeVore","sequence":"additional","affiliation":[{"name":"Fetal Diagnostics Centers  Pasadena California USA"},{"name":"Department of Obstetrics and Gynecology Division of Maternal\u2010Fetal Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Evelina London Children's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric A. P.","family":"Steegers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Fetal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Attie T. J. I.","family":"Go","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Fetal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me M. J.","family":"Cornette","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Division of Fetal Medicine Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2008.02.006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2009.11.018"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12131"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2012.12.004"},{"key":"e_1_2_12_6_1","first-page":"85","article-title":"Speckle\u2010tracking Imaging, Principles and Clinical Applications: A Review for Clinical Cardiologists","author":"Fabiani I.","year":"2016","journal-title":"Echocardiography in Heart Failure and Cardiac Electrophysiology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14454"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.111.086348"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500022"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.10.007"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.04.002"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2023.11.003"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108175.2008.00761.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.08.003"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2007.05.007"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.08060"},{"key":"e_1_2_12_17_1","first-page":"63","article-title":"Fetal Myocardial Deformation Measured With 2D\u2010STE: Longitudinal Prospective Cohort Study in 124 Healthy Fetuses","author":"van Oostrum N. H. M.","year":"2021","journal-title":"2D\u2010Speckle Tracking in Pregnancy"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2020.08.052"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335403"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102019\u20100073"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000584"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.07.010"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010151\u20104\u2010200908180\u201000135"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010019\u201000576\u20105"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000065484.95996.af"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/brs.0000000000001061"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa554"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15939"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15987"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010023\u201003131\u2010y"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21989"},{"key":"e_1_2_12_32_1","unstructured":"B. S.GA Wells D.O'Connell J.Peterson V.Welch M.Losos andP.Tugwell.2022. \u201cThe Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta\u2010Analyses \u201dhttps:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2021.07.017"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jep.13159"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334413"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2023.2214663"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-024-03454-4"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15240"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1273413"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2012.06.005"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.03.015"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06857-x"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341717"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11154456"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3939"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2024.06.020"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-024-07376-7"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-021-02770-3"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.06.012"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102298\u20104670"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2022-0379"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.05.008"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.973395"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22164"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-024-03094-y"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19183"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10115"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15862"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.764676"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.868675"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.11.032"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-15-65"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1285391"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp\u201020\u2010224"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2006.11.003"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.047399"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17549"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22826"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.03.013"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.02.013"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T01:25:12Z","timestamp":1731547512000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":69,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/pd.6672"],"URL":"https:\/\/doi.org\/10.1002\/pd.6672","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"assertion":[{"value":"2024-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}