{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T12:49:25Z","timestamp":1788094165247,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100022790","name":"Sophia Foundation","doi-asserted-by":"publisher","award":["CAM 19\u201011"],"award-info":[{"award-number":["CAM 19\u201011"]}],"id":[{"id":"10.13039\/100022790","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess contemporary outcomes of fetuses who underwent open fetal spina bifida surgery in Canada.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Our clinical program prospectively collected outcomes of all consecutive fetuses who underwent open fetal spina bifida closure at the Ontario Fetal Center in Toronto and who were at least 1\u00a0year of age at the time of postnatal follow\u2010up. We gathered information on the need for hydrocephalus treatment, motor function, bladder function, as well as neurodevelopment (Ages and Stages Questionnaire and Bayley's scales of infant development). Developmental outcomes were categorized as \u201cTypical Development,\u201d \u201cPossible Delay,\u201d or \u201cSignificantly Delayed.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 2017 and 2022, 41 fetuses underwent open fetal spina bifida closure. Twenty\u2010four patients (58.5%) responded to the questionnaire at a median age of 46.5\u00a0months. Eight children (33.3%) required CSF diversion procedures. Bladder management included clean intermittent catheterization (43.5%), spontaneous voiding (34.8%), or both (21.7%), with 43.5% needing medication for overactive bladder. All patients could sit independently, with 50% walking outside and 50% crawling indoors. Among those walking outdoors (50%), 25% did so without orthotics or aid, 58.3% with orthotics, and 16.7% required additional walking aids. Most children demonstrated typical communication and problem\u2010solving skills (79.2%), while gross motor development was significantly delayed in 91.7% of cases. Fine motor skills varied, with 56.5% showing typical development and 34.8% possibly experiencing delays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study showed a mixed developmental profile among patients who underwent open fetal spina bifida repair, consistent with the MOMs trial findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6689","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T09:43:55Z","timestamp":1729331035000},"page":"1635-1640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Contemporary Outcomes of a National Fetal Spina Bifida Surgery Service"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9667-8486","authenticated-orcid":false,"given":"Charlotte C.","family":"Kik","sequence":"first","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Department of Obstetrics and Gynaecology Division of Obstetrics and Fetal Medicine Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yada","family":"Kunpalin","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhaya V.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Department of Surgery Hospital for Sick Children and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Urology Hospital for Sick Children and University of Toronto  Toronto Canada"},{"name":"Spina Bifida Clinic Holland Bloorview Kids Rehabilitation Hospital  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimrah","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Ryan","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4457-0940","authenticated-orcid":false,"given":"Philip L. J.","family":"Dekoninck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Division of Obstetrics and Fetal Medicine Erasmus MC University Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige T.","family":"Church","sequence":"additional","affiliation":[{"name":"Spina Bifida Clinic Holland Bloorview Kids Rehabilitation Hospital  Toronto Canada"},{"name":"Boston Children's Hospital Neonatology &amp; Developmental Behavioral Pediatrics  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armaan","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery Department of Surgery Hospital for Sick Children and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamini","family":"Raghuram","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mount Sinai Hospital and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Mount Sinai Hospital and University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3034-6905","authenticated-orcid":false,"given":"Tim","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Fetal Medicine Unit Department of Obstetrics and Gynaecology Mount Sinai Hospital and University of Toronto  Toronto Canada"},{"name":"Ontario Fetal Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010020\u201004824\u20108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12603"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra2116032"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010319\u201097928\u20101_10"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1014379"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000500049"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5996"},{"key":"e_1_2_11_9_1","unstructured":"Diagnosis ISfP Fetal Surgery MAP accessed October 15 2023 https:\/\/ispdhome.org\/ISPD\/Fetal_Surgery_Map\/index.html."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2020.10.014"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471\u20100528.17557"},{"key":"e_1_2_11_12_1","first-page":"1","article-title":"CDC Growth Charts: United States","volume":"314","author":"Kuczmarski R. 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