{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T22:27:59Z","timestamp":1781476079857,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study explored prenatal ultrasound markers in patients with anorectal malformations (ARMs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients treated for ARM in our institution from January 2014 to December 2021 with an available expert fetal anomaly scan (eFAS) were reviewed. The eFAS images were assessed to evaluate the fetal anus, specifically by identifying hyperechoic anal mucosa surrounded by hypoechoic anal sphincter, referred to as \u201ctarget sign\u201d (TS). Furthermore, indirect signs of ARM were assessed and correlated with postnatal clinical symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 115 patients treated for ARM, 32 mothers underwent eFAS. TS was assessed in 22 fetuses, of which 17 (77.3%) had an absent or abnormal TS. Of the patients with a postnatally confirmed complex type of ARM, 90% had an absent or abnormal TS. One or more indirect signs of ARM were found in 16 out of 32 fetuses (50.0%), comprising echogenic bowel (<jats:italic>n<\/jats:italic>\u00a0=\u00a03), echogenic meconium (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), dilated intestines (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), echo\u2010lucent cavity behind the urinary bladder (<jats:italic>n<\/jats:italic>\u00a0=\u00a04), abnormal external genitalia (<jats:italic>n<\/jats:italic>\u00a0=\u00a06), and polyhydramnios (<jats:italic>n<\/jats:italic>\u00a0=\u00a05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective cohort study provides valuable insights into the potential role of TS assessment and indirect signs in the prenatal diagnosis of ARM. Future studies should further validate our findings and elicit whether TS assessment should be incorporated into prenatal screening protocols.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6723","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T02:40:01Z","timestamp":1733452801000},"page":"35-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prenatal Ultrasound in the Diagnosis of Anorectal Malformations: Correlating Prenatal Signs With Postnatal Outcomes"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7195-568X","authenticated-orcid":false,"given":"D.","family":"Huijgen","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Erasmus MC Sophia  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. P.","family":"Versteegh","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Erasmus MC Sophia  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. M. H.","family":"Wijnen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Erasmus MC Sophia  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Galjaard","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Subdivision of Obstetrics and Fetal Medicine Erasmus MC Sophia  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2427-7269","authenticated-orcid":false,"given":"N. C. J.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Subdivision of Obstetrics and Fetal Medicine Erasmus MC Sophia  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E. J.","family":"Sloots","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Erasmus MC Sophia  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750\u20101172\u20102\u201033"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2007.04.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41390\u2010019\u20100561\u2010y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101609020"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.108859"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010019\u201004513\u20102"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.08056"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.9083"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4472"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14836"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2011.30.1.37"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3862"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970151204"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2014.03.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00499460"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010010\u20102685\u20103"},{"key":"e_1_2_11_18_1","volume-title":"Dutch Association for Obstetrics and Gynecology,","year":"2019"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.08.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010020\u201004840\u20108"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000526231"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4836"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20359"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383\u2010022\u201005204\u20100"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T14:42:28Z","timestamp":1748356948000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,5]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/pd.6723"],"URL":"https:\/\/doi.org\/10.1002\/pd.6723","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,5]]},"assertion":[{"value":"2024-06-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}