{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:20:48Z","timestamp":1772983248353,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report our recent experience with prenatal detection of significant cardiovascular malformations (CVMs) in Nevada's state\u2010wide maternal population receiving prenatal care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We queried our databases for those with significant CVMs diagnosed pre\u2010 or postnatally between May 1, 2021, and April 30, 2024. We defined CVMs as those that required, would have required, or will likely require a therapeutic procedure in the first 12\u00a0months. Additionally, we included those with atrioventricular and ventriculoarterial discordance and left isomeric situs, both unaccompanied by additional CVMs, and congenital complete heart block. We defined routine prenatal care as obstetric care, which included at least one fetal anatomical survey ultrasound.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We identified 390 cases of significant CVMs. Of the 390 cases, 359 (92%) had prenatal care over the three\u2010year observation period, with prenatal detection rates for the three 12\u2010month intervals: 76% (87\/115), 87% (94\/108), and 95% (129\/136) respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001 by chi\u2010square). A total of 310 prenatal diagnoses were made from comprehensive fetal echocardiograms performed on 8397 pregnant women at maternal\u2010fetal\u2010medicine centers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To our knowledge, these results represent the highest prenatal detection rate for significant CVMs, in a state\u2010wide maternal population in the United States.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6739","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T11:51:16Z","timestamp":1735645876000},"page":"196-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Approaching Universal Prenatal Detection of Significant Cardiovascular Malformations in Nevada"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5446-268X","authenticated-orcid":false,"given":"William N.","family":"Evans","sequence":"first","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3472-9217","authenticated-orcid":false,"given":"Ruben J.","family":"Acherman","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrinka T.","family":"Kip","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Reno  Reno Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos F.","family":"Luna","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Ludwick","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Reno  Reno Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Rollins","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Castillo","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina W.","family":"Kwan","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpi","family":"Garg","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Reno  Reno Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1198-5787","authenticated-orcid":false,"given":"Humberto","family":"Restrepo","sequence":"additional","affiliation":[{"name":"Children's Heart Center Nevada  Las Vegas Nevada USA"},{"name":"Kirk Kerkorian School of Medicine Department of Pediatrics Division of Pediatric Cardiology University of Nevada Las Vegas  Las Vegas Nevada USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1047951117002682"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.08.056"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.12.1715"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2007.26.12.1639"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010014\u20100996\u20101"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135119873847"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469\u20100705.2001.00414.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2023.04.014"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2021.101385"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34130"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2021.101433"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.optechstcvs.2020.07.001"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023\u2010022\u201002515\u20102"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010024\u201006350\u20100"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.01.025"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6805a3"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011\u20101317"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2006.00551.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-6773.2006.00550.x"},{"key":"e_1_2_10_21_1","unstructured":"Centers for Disease Control and Prevention: National Center for Health Statistics https:\/\/www.cdc.gov\/nchs\/fastats\/state\u2010and\u2010territorial\u2010data.htm. Accessed March 30 2024."},{"key":"e_1_2_10_22_1","unstructured":"American Health Rankings: United Health Foundation https:\/\/www.americashealthrankings.org\/explore\/measures\/Uninsured_women\/NV. Accessed April 25 2024."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014\u20103783"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6409"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010028139"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22167"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246\u2010012\u20100526\u2010y"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15979"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.109.192576"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12379"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12611"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.108.802868"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5864"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.120.053062"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.02.040"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pd.6739","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:06:27Z","timestamp":1772960787000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,31]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/pd.6739"],"URL":"https:\/\/doi.org\/10.1002\/pd.6739","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,31]]},"assertion":[{"value":"2024-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}