{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:25:50Z","timestamp":1788513950855,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002102","name":"King's Health Partners","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR301448"],"award-info":[{"award-number":["NIHR301448"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT220160\/Z\/20\/Z"],"award-info":[{"award-number":["WT220160\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To use artificial intelligence (AI) to automatically extract video clips of the fetal heart from a stream of ultrasound video, and to assess the performance of these when used for remote second review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a dataset from a previous clinical trial of AI to assist in fetal ultrasound scanning, AI was used to automatically extract video clips of the fetal heart from ultrasound scans of 48 fetuses in which the diagnosis was known: 24 normal and 24 with congenital heart disease (CHD). These, and manually still saved images, were shown in a random order to expert clinicians, who were asked to detect cardiac abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The initial manual scan had a sensitivity of 0.792 and specificity of 0.917 for detecting CHD in this cohort. The addition of second review improved the sensitivity to 0.975 using video clips, which was significantly higher than using still images (0.892, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002). There was a significant drop in specificity to 0.767 and 0.833 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) for the video and still method, respectively, which were statistically similar to each other (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.117). The median review time was 1.0\u00a0min (IQR 0.71) for the still images, and 3.75\u00a0min (IQR 3.12) for the AI\u2010generated video clips.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AI can be used to automatically extract fetal cardiac video clips, and these can be used for remote second review to improve detection rates. Video clips are superior to still images, but both methods result in a significant drop in specificity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6757","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T06:08:51Z","timestamp":1738908531000},"page":"531-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Video Clip Extraction From Fetal Ultrasound Scans Using Artificial Intelligence to Allow Remote Second Expert Review for Congenital Heart Disease"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8391-7903","authenticated-orcid":false,"given":"Thomas G.","family":"Day","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"},{"name":"Fetal Cardiology Unit Department of Congenital Heart Disease Evelina London Children\u2019s Healthcare Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Venturini","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel F.","family":"Budd","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Farruggia","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Matthew","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vita","family":"Zidere","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Department of Congenital Heart Disease Evelina London Children\u2019s Healthcare Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Vigneswaran","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Department of Congenital Heart Disease Evelina London Children\u2019s Healthcare Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Bo","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Royal Brompton and Harefield Hospitals Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Savis","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Department of Congenital Heart Disease Evelina London Children\u2019s Healthcare Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Wolfenden","sequence":"additional","affiliation":[{"name":"Fetal Cardiology Unit Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Simpson","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"},{"name":"Fetal Cardiology Unit Department of Congenital Heart Disease Evelina London Children\u2019s Healthcare Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Hajnal","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Kainz","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"},{"name":"Department of Computing Imperial College London  London UK"},{"name":"Image Data Exploration and Analysis Lab Friedrich\u2010Alexander\u2010Universitat Erlangen\u2010Nurnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Razavi","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences King\u2019s College London  London UK"},{"name":"Fetal Cardiology Unit Department of Congenital Heart Disease Evelina London Children\u2019s Healthcare Guy\u2019s and St Thomas\u2019 NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"NHS Fetal Anomaly Screening Programme Handbook","author":"NHS Screening Programmes","year":"2018"},{"key":"e_1_2_11_3_1","unstructured":"National Congenital Heart Disease Audit Summary Report(National Institute for Cardiovascular Outcomes Research 2021)."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010028139"},{"key":"e_1_2_11_5_1","unstructured":"National Congenital Anomaly and Rare Disease Reporting Service Annual Data2019 accessed June 21 2022.https:\/\/www.gov.uk\/government\/publications\/ncardrs\u2010congenital\u2010anomaly\u2010annual\u2010data."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010018\u20100195\u20106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1258\/jtt.2008.080401"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/jtt.2011.110503"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.21974"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.05.23.24307329"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6445"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.27577"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001342\u20105"},{"key":"e_1_2_11_14_1","first-page":"759","article-title":"Deep Learning Model for Prenatal Congenital Heart Disease (CHD) Screening Can Be Applied to Retrospective Imaging From the Community Setting, Outperforming Initial Clinical Detection in a Well\u2010Annotated Cohort","volume":"60","author":"Athalye C.","year":"2023","journal-title":"Ultrasound in Obstetrics and Gynecology"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6757","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T13:36:47Z","timestamp":1744378607000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/pd.6757"],"URL":"https:\/\/doi.org\/10.1002\/pd.6757","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"2024-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}