{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:39Z","timestamp":1786978299254,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The role of prenatal urinoma in lower urinary tract obstruction (LUTO) such as posterior urethral valves (PUV) is debated. We aimed to describe the risk factors associated with fetal urinoma and the association between fetal urinoma and postnatal renal function before 2\u00a0years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective multicenter case\u2010control study from 2000 to 2018 included pregnant patients with suspected LUTO in their male fetus on prenatal ultrasound and postnatal confirmation of PUV. The exposure criterion was prenatal urinoma. The main composit outcome (MCO) was chronic kidney disease stage 3 or higher (CKD3+) before 2\u00a0years or death. Descriptive analyses of patient data and crude and multivariate logistic regression analyses were performed in an intent\u2010to\u2010treat fashion, thus including lost\u2010to\u2010follow\u2010up patients. Ethical approval # 20.144.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We included 299 patients, of whom 39 (13%) had prenatal urinoma. Thirty\u2010eight patients had a termination of pregnancy (12.7%). Sixty\u2010four (24.5%) patients'children were MCO positive. Twenty\u2010one children were lost\u2010to\u2010follow\u2010up, including one prenatal urinoma. Thirty\u2010nine (60.9%) of the remaining children had CKD3+ before the age of two, of whom 6 had a prenatal urinoma (9.4%). Among the 197 children negative to the MCO, 24 had a prenatal urinoma (12.2%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.42). Four died neonatally. In livebirth patients, prenatal urinoma was associated with obstetrical complications (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), prenatal bloodcord sample for fetal beta2\u2010microglobulin (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) and uro\u2010amniotic shunt (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01). Patients with prenatal urinoma more often presented with oligohydramnios (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) and dilated posterior urethra (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) and were less likely to have urinary tract infections (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02), although their DMSA scan was more often altered (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). Prenatal urinoma was not significantly associated with CKD3+ before 2\u00a0years (OR\u00a0=\u00a00.56, CI98%\u00a0=\u00a00.20\u20131.39,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.23).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Renal function in infants with PUV was not worsened by the presence of a prenatal urinoma. Thus, there should not be any more pejorative message conveyed to concerned couples apart from other already known prenatal poor prognosis risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pd.6773","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T01:00:31Z","timestamp":1741914031000},"page":"1013-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fetal Urinoma Secondary to Posterior Urethral Valve and Its Association to Postnatal Renal Function: A Multicenter Retrospective Study"],"prefix":"10.1002","volume":"45","author":[{"given":"Flore\u2010Anne","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Gynecology, Obstetrics and Reproductive Medicine CHU Rennes Universit\u00e9 de Rennes  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3617-4849","authenticated-orcid":false,"given":"Matthieu","family":"Peycelon","sequence":"additional","affiliation":[{"name":"Department of Pediatric Urology National Reference Center for Rare Urinary Tract Malformations (MARVU) University Hospital Robert\u2010Debre APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Vinit","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology H\u00f4pital Necker\u2010Enfants Malades APHP Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Planchamp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery CHU Purpan Universit\u00e9 de Toulouse  Toulouse 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