{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T07:23:50Z","timestamp":1774941830991,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Prenatal repair of myelomeningocele (MMC) improves fetal outcomes; however, open uterine surgery has associated morbidities. We report our institutional outcomes following laparotomy\u2010assisted fetoscopic MMC repair.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational study, including a 1\u2010year follow\u2010up period, was conducted from April 2018 to March 2024. Similar study considerations from the 2011 Management of Myelomeningocele Study (MOMS) and 2019 MOMS Plus study were applied. Laparotomy\u2010assisted repair utilized an extended Pfannenstiel incision and vertical midline fascial incision to exteriorize the uterus for trocar placement. Primary outcomes were ventriculoperitoneal (VP) shunt at 12\u00a0months or perinatal death. Secondary outcomes included select maternal and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 39 qualifying patients, 10 underwent repair at a median GA of 25w4d (IQR 25w0d\u201326w6d). All pregnancies resulted in live births in a median GA of 36w1d (IQR 32w2d\u201337w0d). Preterm premature rupture of membranes was observed (PPROM) in five patients. Four patients delivered vaginally without complications. All trocar sites were noted to be intact at the time of cesarean deliveries. Two neonates required revision of MMC closure after birth. One patient required a VP shunt placement at 4\u00a0months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Early results at our center demonstrate that laparotomy\u2010assisted fetoscopic MMC repair is a safe option for qualified patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pd.6781","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:14:53Z","timestamp":1743142493000},"page":"658-667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcomes Following Fetoscopic Repair of Myelomeningocele: A Prospective Single\u2010Center Experience"],"prefix":"10.1002","volume":"45","author":[{"given":"Vincent","family":"Duron","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Morgan Stanley Children\u2019s Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Feldstein","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery Department of Neurosurgery Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Morgan Stanley Children\u2019s Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Schmoke","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Morgan Stanley Children\u2019s Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3224-3204","authenticated-orcid":false,"given":"Yeu Sanz","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Morgan Stanley Children\u2019s Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyler","family":"Shirel","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Regenerative Medicine Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Morgan Stanley Children\u2019s Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Ring","sequence":"additional","affiliation":[{"name":"Division of Obstetric Anesthesia Department of Anesthesia Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Landau","sequence":"additional","affiliation":[{"name":"Division of Obstetric Anesthesia Department of Anesthesia Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Azizi","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Regenerative Medicine Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Morgan Stanley Children\u2019s Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalie","family":"Ingrassia","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2840-4612","authenticated-orcid":false,"given":"Noelle","family":"Breslin","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Columbia University Irving Medical Center \/ NewYork\u2010Presbyterian Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2116032"},{"key":"e_1_2_12_3_1","volume-title":"Meningomyelocele","author":"Sahni M.","year":"2023"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2022.06.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1891\/11\u2010t\u2010704"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1014379"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.12.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5421"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000479505"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000001941"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.05.044"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22116"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000518507"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525552"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6119"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499484"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12155151"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000005177"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20308"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.12.317"}],"container-title":["Prenatal Diagnosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pd.6781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T13:45:58Z","timestamp":1746539158000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1002\/pd.6781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/pd.6781"],"URL":"https:\/\/doi.org\/10.1002\/pd.6781","archive":["Portico"],"relation":{},"ISSN":["0197-3851","1097-0223"],"issn-type":[{"value":"0197-3851","type":"print"},{"value":"1097-0223","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"2024-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}